p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade

Squamous cell carcinoma driven by human papillomavirus (HPV) is more sensitive to DNA-damaging therapies than its HPV-negative counterpart. Here, we show that p16, the clinically used surrogate for HPV positivity, renders cells more sensitive to radiotherapy via a ubiquitin-dependent signaling pathw...

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Detalles Bibliográficos
Autores principales: Molkentine, David P., Molkentine, Jessica M., Bridges, Kathleen A., Valdecanas, David R., Dhawan, Annika, Bahri, Reshub, Hefner, Andrew J., Kumar, Manish, Yang, Liangpeng, Abdelhakiem, Mohamed, Pifer, Phillip M., Sandulache, Vlad, Sheth, Aakash, Beadle, Beth M., Thames, Howard D., Mason, Kathryn A., Pickering, Curtis R., Meyn, Raymond E., Skinner, Heath D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Translational Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136619/
https://www.ncbi.nlm.nih.gov/pubmed/34965932
http://dx.doi.org/10.1158/0008-5472.CAN-21-2101

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