Prognostic value of circulating endothelial cells in glioblastoma patients: a pilot study

AIM: Glioblastoma (GB) is an aggressive tumor type and the detection of circulating endothelial cells (CECs) in peripheral blood has been related to angiogenesis. MATERIALS & METHODS: A prospective single-center pilot study of CEC detection at diagnosis in 22 patients with GB was performed, usin...

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Detalles Bibliográficos
Autores principales: Vaz Salgado, María Angeles, Earl, Julie, Berrocal, Victor Rodriguez, Arrieta, Freddy Salge, Gomez, Ana, Sepulveda-Sanchez, Juan Manuel, Perez-Nuñez, Ángel, de la Fuente, Elena Corral, Lourido, Daniel, Villamayor, María, Pian, Hector, Muriel, Alfonso, Rossi, Elisabetta, Zamarchi, Rita, Carrato, Alfredo, Ley, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136629/
https://www.ncbi.nlm.nih.gov/pubmed/35662744
http://dx.doi.org/10.2144/fsoa-2022-0008
Descripción
Sumario:AIM: Glioblastoma (GB) is an aggressive tumor type and the detection of circulating endothelial cells (CECs) in peripheral blood has been related to angiogenesis. MATERIALS & METHODS: A prospective single-center pilot study of CEC detection at diagnosis in 22 patients with GB was performed, using the US FDA-approved CellSearch system. RESULTS: A CEC cutoff value was estimated using a receiver operating curve (ROC) and patients were classified into two groups: <40 CEC/4 ml and >40 CEC/4 ml blood. Median overall survival was 25.33 months for group 1 and 8.23 months for group 2 cases (p = 0.02). There was no correlation between CEC and PWI (perfusion-weighted imaging) RM. CONCLUSION: CEC detection has a prognostic value in GB cases at diagnosis.

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