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Morphofunctional Characteristics of Erythrocytes and Blood Erythropoietin Level in Patients as Predictors of Severe Course of COVID-19

Morphological and functional characteristics of erythrocytes, hemoglobin, and erythropoietin level in the venous blood were evaluated by laser interference microscopy, Raman spectroscopy with a short-focus extreme aperture lens monochromator, and by ELISA, respectively, in 30 patients with verified...

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Autores principales: Revin, V. V., Balykova, L. A., Radaeva, O. A., Shchapov, V. V., Revina, E. S., Pinyaev, S. I., Kostina, Yu. A., Kozlov, E. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136801/
https://www.ncbi.nlm.nih.gov/pubmed/35622261
http://dx.doi.org/10.1007/s10517-022-05490-7
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author Revin, V. V.
Balykova, L. A.
Radaeva, O. A.
Shchapov, V. V.
Revina, E. S.
Pinyaev, S. I.
Kostina, Yu. A.
Kozlov, E. D.
author_facet Revin, V. V.
Balykova, L. A.
Radaeva, O. A.
Shchapov, V. V.
Revina, E. S.
Pinyaev, S. I.
Kostina, Yu. A.
Kozlov, E. D.
author_sort Revin, V. V.
collection PubMed
description Morphological and functional characteristics of erythrocytes, hemoglobin, and erythropoietin level in the venous blood were evaluated by laser interference microscopy, Raman spectroscopy with a short-focus extreme aperture lens monochromator, and by ELISA, respectively, in 30 patients with verified moderate COVID-19 at the time of hospitalization and 30 healthy volunteers. The patients whose course of COVID-19 has worsened to critical by day 5 had already had lower (p<0.001) indicators at the time of hospitalization such as the area and thickness of erythrocytes, the hemoglobin distribution and packing density, hemoglobin conformation index (I(1355)/I(1550))/(I(1375)/I(1580)) reflecting its oxygen affinity, and blood erythropoietin content. Our findings suggest that these characteristics of erythrocytes, hemoglobin, and erythropoietin can serve as potential predictors of COVID-19 aggravation in hospitalized patients.
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spelling pubmed-91368012022-06-02 Morphofunctional Characteristics of Erythrocytes and Blood Erythropoietin Level in Patients as Predictors of Severe Course of COVID-19 Revin, V. V. Balykova, L. A. Radaeva, O. A. Shchapov, V. V. Revina, E. S. Pinyaev, S. I. Kostina, Yu. A. Kozlov, E. D. Bull Exp Biol Med Immunology and Microbiology Morphological and functional characteristics of erythrocytes, hemoglobin, and erythropoietin level in the venous blood were evaluated by laser interference microscopy, Raman spectroscopy with a short-focus extreme aperture lens monochromator, and by ELISA, respectively, in 30 patients with verified moderate COVID-19 at the time of hospitalization and 30 healthy volunteers. The patients whose course of COVID-19 has worsened to critical by day 5 had already had lower (p<0.001) indicators at the time of hospitalization such as the area and thickness of erythrocytes, the hemoglobin distribution and packing density, hemoglobin conformation index (I(1355)/I(1550))/(I(1375)/I(1580)) reflecting its oxygen affinity, and blood erythropoietin content. Our findings suggest that these characteristics of erythrocytes, hemoglobin, and erythropoietin can serve as potential predictors of COVID-19 aggravation in hospitalized patients. Springer US 2022-05-27 2022 /pmc/articles/PMC9136801/ /pubmed/35622261 http://dx.doi.org/10.1007/s10517-022-05490-7 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Immunology and Microbiology
Revin, V. V.
Balykova, L. A.
Radaeva, O. A.
Shchapov, V. V.
Revina, E. S.
Pinyaev, S. I.
Kostina, Yu. A.
Kozlov, E. D.
Morphofunctional Characteristics of Erythrocytes and Blood Erythropoietin Level in Patients as Predictors of Severe Course of COVID-19
title Morphofunctional Characteristics of Erythrocytes and Blood Erythropoietin Level in Patients as Predictors of Severe Course of COVID-19
title_full Morphofunctional Characteristics of Erythrocytes and Blood Erythropoietin Level in Patients as Predictors of Severe Course of COVID-19
title_fullStr Morphofunctional Characteristics of Erythrocytes and Blood Erythropoietin Level in Patients as Predictors of Severe Course of COVID-19
title_full_unstemmed Morphofunctional Characteristics of Erythrocytes and Blood Erythropoietin Level in Patients as Predictors of Severe Course of COVID-19
title_short Morphofunctional Characteristics of Erythrocytes and Blood Erythropoietin Level in Patients as Predictors of Severe Course of COVID-19
title_sort morphofunctional characteristics of erythrocytes and blood erythropoietin level in patients as predictors of severe course of covid-19
topic Immunology and Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136801/
https://www.ncbi.nlm.nih.gov/pubmed/35622261
http://dx.doi.org/10.1007/s10517-022-05490-7
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