Development of a First-in-Class Small-Molecule Inhibitor of the C-Terminal Hsp90 Dimerization

[Image: see text] Heat shock proteins 90 (Hsp90) are promising therapeutic targets due to their involvement in stabilizing several aberrantly expressed oncoproteins. In cancerous cells, Hsp90 expression is elevated, thereby exerting antiapoptotic effects, which is essential for the malignant transfo...

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Detalles Bibliográficos
Autores principales: Bhatia, Sanil, Spanier, Lukas, Bickel, David, Dienstbier, Niklas, Woloschin, Vitalij, Vogt, Melina, Pols, Henrik, Lungerich, Beate, Reiners, Jens, Aghaallaei, Narges, Diedrich, Daniela, Frieg, Benedikt, Schliehe-Diecks, Julian, Bopp, Bertan, Lang, Franziska, Gopalswamy, Mohanraj, Loschwitz, Jennifer, Bajohgli, Baubak, Skokowa, Julia, Borkhardt, Arndt, Hauer, Julia, Hansen, Finn K., Smits, Sander H. J., Jose, Joachim, Gohlke, Holger, Kurz, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9136973/
https://www.ncbi.nlm.nih.gov/pubmed/35647282
http://dx.doi.org/10.1021/acscentsci.2c00013

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