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SIRT1 mediates nutritional regulation of SREBP-1c-driven hepatic PNPLA3 transcription via modulation of H3k9 acetylation

BACKGROUND: Patatin-like phospholipase domain containing 3 (PNPLA3) is the main nonalcoholic fatty liver disease (NAFLD) susceptibility. Its expression is regulated tightly by nutritional and energy status, but the mechanism of epigenetic regulation of PNPLA3 gene by nutritional dietary factors has...

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Detalles Bibliográficos
Autores principales:	Xu, Xiao, Deng, Xiaojie, Chen, Yunzhi, Xu, Wen, Xu, Fen, Liang, Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137095/ https://www.ncbi.nlm.nih.gov/pubmed/35624499 http://dx.doi.org/10.1186/s41021-022-00246-1

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