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The HSP90 inhibitor KW-2478 depletes the malignancy of BCR/ABL and overcomes the imatinib-resistance caused by BCR/ABL amplification

BACKGROUND: With the widespread clinical application of tyrosine kinase inhibitors (TKIs), an increasing number of chronic myeloid leukaemia (CML) patients have developed resistance or intolerance to TKIs. BCR/ABL is the oncoprotein of CML. HSP90 is an essential chaperone of BCR/ABL and plays an imp...

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Detalles Bibliográficos
Autores principales:	Zeng, Dachuan, Gao, Miao, Zheng, Renren, Qin, Run, He, Wei, Liu, Suotian, Wei, Wei, Huang, Zhenglan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137153/ https://www.ncbi.nlm.nih.gov/pubmed/35624462 http://dx.doi.org/10.1186/s40164-022-00287-w

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