Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1/RIP3-exosome axis

BACKGROUND: Cerebral ischemia-reperfusion injury (CIRI) refers to a secondary brain injury that can occur when the blood supply to the ischemic brain tissue is restored. However, the mechanism underlying such injury remains elusive. METHODS: The 150 male C57 mice underwent middle cerebral artery occ...

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Detalles Bibliográficos
Autores principales: Zeng, Xue, Zhang, Yun-Dong, Ma, Rui-Yan, Chen, Yuan-Jing, Xiang, Xin-Ming, Hou, Dong-Yao, Li, Xue-Han, Huang, He, Li, Tao, Duan, Chen-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137164/
https://www.ncbi.nlm.nih.gov/pubmed/35624495
http://dx.doi.org/10.1186/s40779-022-00383-2

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