Early life vitamin D depletion and mechanical loading determine methylation changes in the RUNX2, RXRA, and osterix promoters in mice

BACKGROUND: Early life vitamin D exposure is linked to later skeletal health with maternal vitamin D status in pregnancy associated with neonatal bone mass. The MAVIDOS study has demonstrated that vitamin D supplementation leads to reduced RXRA DNA methylation. Mice exposed to early life vitamin D d...

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Detalles Bibliográficos
Autores principales: Krstic, Nevena, Bishop, Nick, Curtis, Beth, Cooper, Cyrus, Harvey, Nick, Lilycrop, Karen, Murray, Robert, Owen, Robert, Reilly, Gwen, Skerry, Tim, Borg, Steph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137183/
https://www.ncbi.nlm.nih.gov/pubmed/35619053
http://dx.doi.org/10.1186/s12263-022-00711-0

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