Dextran sulfate prevents excess aggregation of human pluripotent stem cells in 3D culture by inhibiting ICAM1 expression coupled with down-regulating E-cadherin through activating the Wnt signaling pathway

BACKGROUND: Human pluripotent stem cells (hPSCs) have great potential in applications for regenerative medicine and drug development. However, 3D suspension culture systems for clinical-grade hPSC large-scale production have been a major challenge. Accumulating evidence has demonstrated that the add...

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Detalles Bibliográficos
Autores principales: Wu, Haibin, Tang, Xianglian, Wang, Yiyu, Wang, Ning, Chen, Qicong, Xie, Jinghe, Liu, Shoupei, Zhong, Zhiyong, Qiu, Yaqi, Situ, Ping, Zern, Mark A., Wang, Jue, Chen, Honglin, Duan, Yuyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137216/
https://www.ncbi.nlm.nih.gov/pubmed/35619172
http://dx.doi.org/10.1186/s13287-022-02890-4

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