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Local and Global Protein Interactions Contribute to Residue Entrenchment in Beta-Lactamase TEM-1

Due to their rapid evolution and their impact on healthcare, beta-lactamases, protein degrading beta-lactam antibiotics, are used as generic models of protein evolution. Therefore, we investigated the mutation effects in two distant beta-lactamases, TEM-1 and CTX-M-15. Interestingly, we found a site...

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Detalles Bibliográficos
Autores principales:	Birgy, André, Magnan, Mélanie, Hobson, Claire Amaris, Figliuzzi, Matteo, Panigoni, Karine, Codde, Cyrielle, Tenaillon, Olivier, Jacquier, Hervé
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137480/ https://www.ncbi.nlm.nih.gov/pubmed/35625296 http://dx.doi.org/10.3390/antibiotics11050652

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