Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen

Drug-induced liver injury (DILI) development is commonly associated with acetaminophen (APAP) overdose, where glutathione scavenging leads to mitochondrial dysfunction and hepatocyte death. DILI is a severe disorder without effective late-stage treatment, since N-acetyl cysteine must be administered...

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Detalles Bibliográficos
Autores principales: Rodríguez-Agudo, Rubén, Goikoetxea-Usandizaga, Naroa, Serrano-Maciá, Marina, Fernández-Tussy, Pablo, Fernández-Ramos, David, Lachiondo-Ortega, Sofía, González-Recio, Irene, Gil-Pitarch, Clàudia, Mercado-Gómez, María, Morán, Laura, Bizkarguenaga, Maider, Lopitz-Otsoa, Fernando, Petrov, Petar, Bravo, Miren, Van Liempd, Sebastiaan Martijn, Falcon-Perez, Juan Manuel, Zabala-Letona, Amaia, Carracedo, Arkaitz, Castell, Jose Vicente, Jover, Ramiro, Martínez-Cruz, Luis Alfonso, Delgado, Teresa Cardoso, Cubero, Francisco Javier, Lucena, María Isabel, Andrade, Raúl Jesús, Mabe, Jon, Simón, Jorge, Martínez-Chantar, María Luz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137496/
https://www.ncbi.nlm.nih.gov/pubmed/35624761
http://dx.doi.org/10.3390/antiox11050897

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