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Apitherapy and Periodontal Disease: Insights into In Vitro, In Vivo, and Clinical Studies
Periodontal diseases are caused mainly by inflammation of the gums and bones surrounding the teeth or by dysbiosis of the oral microbiome, and the Global Burden of Disease study (2019) reported that periodontal disease affects 20–50% of the global population. In recent years, more preference has bee...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137511/ https://www.ncbi.nlm.nih.gov/pubmed/35624686 http://dx.doi.org/10.3390/antiox11050823 |
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author | Kumar, Manoj Prakash, Suraj Radha, Lorenzo, José M. Chandran, Deepak Dhumal, Sangram Dey, Abhijit Senapathy, Marisennayya Rais, Nadeem Singh, Surinder Kalkreuter, Phillip Damale, Rahul D. Natta, Suman Vishvanathan, Marthandan Sathyaseelan, Sangeetha Kizhakkumkara Rajalingam, Sureshkumar Viswanathan, Sabareeshwari Murugesan, Yasodha Muthukumar, Muthamilselvan Jayaraman, Aravind Kalirajan, Murugasridevi Selim, Samy Amarowicz, Ryszard Mekhemar, Mohamed |
author_facet | Kumar, Manoj Prakash, Suraj Radha, Lorenzo, José M. Chandran, Deepak Dhumal, Sangram Dey, Abhijit Senapathy, Marisennayya Rais, Nadeem Singh, Surinder Kalkreuter, Phillip Damale, Rahul D. Natta, Suman Vishvanathan, Marthandan Sathyaseelan, Sangeetha Kizhakkumkara Rajalingam, Sureshkumar Viswanathan, Sabareeshwari Murugesan, Yasodha Muthukumar, Muthamilselvan Jayaraman, Aravind Kalirajan, Murugasridevi Selim, Samy Amarowicz, Ryszard Mekhemar, Mohamed |
author_sort | Kumar, Manoj |
collection | PubMed |
description | Periodontal diseases are caused mainly by inflammation of the gums and bones surrounding the teeth or by dysbiosis of the oral microbiome, and the Global Burden of Disease study (2019) reported that periodontal disease affects 20–50% of the global population. In recent years, more preference has been given to natural therapies compared to synthetic drugs in the treatment of periodontal disease, and several oral care products, such as toothpaste, mouthwash, and dentifrices, have been developed comprising honeybee products, such as propolis, honey, royal jelly, and purified bee venom. In this study, we systematically reviewed the literature on the treatment of periodontitis using honeybee products. A literature search was performed using various databases, including PubMed, Web of Science, ScienceDirect, Scopus, clinicaltrials.gov, and Google Scholar. A total of 31 studies were reviewed using eligibility criteria published between January 2016 and December 2021. In vitro, in vivo, and clinical studies (randomized clinical trials) were included. Based on the results of these studies, honeybee products, such as propolis and purified bee venom, were concluded to be effective and safe for use in the treatment of periodontitis mainly due to their antimicrobial and anti-inflammatory activities. However, to obtain reliable results from randomized clinical trials assessing the effectiveness of honeybee products in periodontal treatment with long-term follow-up, a broader sample size and assessment of various clinical parameters are needed. |
format | Online Article Text |
id | pubmed-9137511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91375112022-05-28 Apitherapy and Periodontal Disease: Insights into In Vitro, In Vivo, and Clinical Studies Kumar, Manoj Prakash, Suraj Radha, Lorenzo, José M. Chandran, Deepak Dhumal, Sangram Dey, Abhijit Senapathy, Marisennayya Rais, Nadeem Singh, Surinder Kalkreuter, Phillip Damale, Rahul D. Natta, Suman Vishvanathan, Marthandan Sathyaseelan, Sangeetha Kizhakkumkara Rajalingam, Sureshkumar Viswanathan, Sabareeshwari Murugesan, Yasodha Muthukumar, Muthamilselvan Jayaraman, Aravind Kalirajan, Murugasridevi Selim, Samy Amarowicz, Ryszard Mekhemar, Mohamed Antioxidants (Basel) Review Periodontal diseases are caused mainly by inflammation of the gums and bones surrounding the teeth or by dysbiosis of the oral microbiome, and the Global Burden of Disease study (2019) reported that periodontal disease affects 20–50% of the global population. In recent years, more preference has been given to natural therapies compared to synthetic drugs in the treatment of periodontal disease, and several oral care products, such as toothpaste, mouthwash, and dentifrices, have been developed comprising honeybee products, such as propolis, honey, royal jelly, and purified bee venom. In this study, we systematically reviewed the literature on the treatment of periodontitis using honeybee products. A literature search was performed using various databases, including PubMed, Web of Science, ScienceDirect, Scopus, clinicaltrials.gov, and Google Scholar. A total of 31 studies were reviewed using eligibility criteria published between January 2016 and December 2021. In vitro, in vivo, and clinical studies (randomized clinical trials) were included. Based on the results of these studies, honeybee products, such as propolis and purified bee venom, were concluded to be effective and safe for use in the treatment of periodontitis mainly due to their antimicrobial and anti-inflammatory activities. However, to obtain reliable results from randomized clinical trials assessing the effectiveness of honeybee products in periodontal treatment with long-term follow-up, a broader sample size and assessment of various clinical parameters are needed. MDPI 2022-04-22 /pmc/articles/PMC9137511/ /pubmed/35624686 http://dx.doi.org/10.3390/antiox11050823 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kumar, Manoj Prakash, Suraj Radha, Lorenzo, José M. Chandran, Deepak Dhumal, Sangram Dey, Abhijit Senapathy, Marisennayya Rais, Nadeem Singh, Surinder Kalkreuter, Phillip Damale, Rahul D. Natta, Suman Vishvanathan, Marthandan Sathyaseelan, Sangeetha Kizhakkumkara Rajalingam, Sureshkumar Viswanathan, Sabareeshwari Murugesan, Yasodha Muthukumar, Muthamilselvan Jayaraman, Aravind Kalirajan, Murugasridevi Selim, Samy Amarowicz, Ryszard Mekhemar, Mohamed Apitherapy and Periodontal Disease: Insights into In Vitro, In Vivo, and Clinical Studies |
title | Apitherapy and Periodontal Disease: Insights into In Vitro, In Vivo, and Clinical Studies |
title_full | Apitherapy and Periodontal Disease: Insights into In Vitro, In Vivo, and Clinical Studies |
title_fullStr | Apitherapy and Periodontal Disease: Insights into In Vitro, In Vivo, and Clinical Studies |
title_full_unstemmed | Apitherapy and Periodontal Disease: Insights into In Vitro, In Vivo, and Clinical Studies |
title_short | Apitherapy and Periodontal Disease: Insights into In Vitro, In Vivo, and Clinical Studies |
title_sort | apitherapy and periodontal disease: insights into in vitro, in vivo, and clinical studies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137511/ https://www.ncbi.nlm.nih.gov/pubmed/35624686 http://dx.doi.org/10.3390/antiox11050823 |
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