Cargando…

Emerging Paradigms in Bioengineering the Lungs

In end-stage lung diseases, the shortage of donor lungs for transplantation and long waiting lists are the main culprits in the significantly increasing number of patient deaths. New strategies to curb this issue are being developed with the help of recent advancements in bioengineering technology,...

Descripción completa

Detalles Bibliográficos
Autores principales: Mohgan, Raxshanaa, Candasamy, Mayuren, Mayuren, Jayashree, Singh, Sachin Kumar, Gupta, Gaurav, Dua, Kamal, Chellappan, Dinesh Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137616/
https://www.ncbi.nlm.nih.gov/pubmed/35621473
http://dx.doi.org/10.3390/bioengineering9050195
_version_ 1784714421481766912
author Mohgan, Raxshanaa
Candasamy, Mayuren
Mayuren, Jayashree
Singh, Sachin Kumar
Gupta, Gaurav
Dua, Kamal
Chellappan, Dinesh Kumar
author_facet Mohgan, Raxshanaa
Candasamy, Mayuren
Mayuren, Jayashree
Singh, Sachin Kumar
Gupta, Gaurav
Dua, Kamal
Chellappan, Dinesh Kumar
author_sort Mohgan, Raxshanaa
collection PubMed
description In end-stage lung diseases, the shortage of donor lungs for transplantation and long waiting lists are the main culprits in the significantly increasing number of patient deaths. New strategies to curb this issue are being developed with the help of recent advancements in bioengineering technology, with the generation of lung scaffolds as a steppingstone. There are various types of lung scaffolds, namely, acellular scaffolds that are developed via decellularization and recellularization techniques, artificial scaffolds that are synthesized using synthetic, biodegradable, and low immunogenic materials, and hybrid scaffolds which combine the advantageous properties of materials in the development of a desirable lung scaffold. There have also been advances in the design of bioreactors in terms of providing an optimal regenerative environment for the maturation of functional lung tissue over time. In this review, the emerging paradigms in the field of lung tissue bioengineering will be discussed.
format Online
Article
Text
id pubmed-9137616
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91376162022-05-28 Emerging Paradigms in Bioengineering the Lungs Mohgan, Raxshanaa Candasamy, Mayuren Mayuren, Jayashree Singh, Sachin Kumar Gupta, Gaurav Dua, Kamal Chellappan, Dinesh Kumar Bioengineering (Basel) Review In end-stage lung diseases, the shortage of donor lungs for transplantation and long waiting lists are the main culprits in the significantly increasing number of patient deaths. New strategies to curb this issue are being developed with the help of recent advancements in bioengineering technology, with the generation of lung scaffolds as a steppingstone. There are various types of lung scaffolds, namely, acellular scaffolds that are developed via decellularization and recellularization techniques, artificial scaffolds that are synthesized using synthetic, biodegradable, and low immunogenic materials, and hybrid scaffolds which combine the advantageous properties of materials in the development of a desirable lung scaffold. There have also been advances in the design of bioreactors in terms of providing an optimal regenerative environment for the maturation of functional lung tissue over time. In this review, the emerging paradigms in the field of lung tissue bioengineering will be discussed. MDPI 2022-05-01 /pmc/articles/PMC9137616/ /pubmed/35621473 http://dx.doi.org/10.3390/bioengineering9050195 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mohgan, Raxshanaa
Candasamy, Mayuren
Mayuren, Jayashree
Singh, Sachin Kumar
Gupta, Gaurav
Dua, Kamal
Chellappan, Dinesh Kumar
Emerging Paradigms in Bioengineering the Lungs
title Emerging Paradigms in Bioengineering the Lungs
title_full Emerging Paradigms in Bioengineering the Lungs
title_fullStr Emerging Paradigms in Bioengineering the Lungs
title_full_unstemmed Emerging Paradigms in Bioengineering the Lungs
title_short Emerging Paradigms in Bioengineering the Lungs
title_sort emerging paradigms in bioengineering the lungs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137616/
https://www.ncbi.nlm.nih.gov/pubmed/35621473
http://dx.doi.org/10.3390/bioengineering9050195
work_keys_str_mv AT mohganraxshanaa emergingparadigmsinbioengineeringthelungs
AT candasamymayuren emergingparadigmsinbioengineeringthelungs
AT mayurenjayashree emergingparadigmsinbioengineeringthelungs
AT singhsachinkumar emergingparadigmsinbioengineeringthelungs
AT guptagaurav emergingparadigmsinbioengineeringthelungs
AT duakamal emergingparadigmsinbioengineeringthelungs
AT chellappandineshkumar emergingparadigmsinbioengineeringthelungs