Soluble Papain to Digest Monoclonal Antibodies; Time and Cost-Effective Method to Obtain Fab Fragment

Antigen binding fragments (Fabs) used in research (e.g., antibody mimetics, antibody-drug conjugate, bispecific antibodies) are frequently obtained by enzymatic digestion of monoclonal antibodies using immobilised papain. Despite obtaining pure Fab, using immobilised papain to digest IgG has limitat...

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Detalles Bibliográficos
Autores principales: Collins, Matthew, Khalili, Hanieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137653/
https://www.ncbi.nlm.nih.gov/pubmed/35621487
http://dx.doi.org/10.3390/bioengineering9050209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137653/
https://www.ncbi.nlm.nih.gov/pubmed/35621487
http://dx.doi.org/10.3390/bioengineering9050209

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