Metabolism Dysregulation in Retinal Diseases and Related Therapies

The human retina, which is part of the central nervous system, has exceptionally high energy demands that requires an efficient metabolism of glucose, lipids, and amino acids. Dysregulation of retinal metabolism disrupts local energy supply and redox balance, contributing to the pathogenesis of dive...

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Autores principales: Chen, Yingying, Coorey, Nathan J., Zhang, Meixia, Zeng, Shaoxue, Madigan, Michele C., Zhang, Xinyuan, Gillies, Mark C., Zhu, Ling, Zhang, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137684/
https://www.ncbi.nlm.nih.gov/pubmed/35624805
http://dx.doi.org/10.3390/antiox11050942
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author Chen, Yingying
Coorey, Nathan J.
Zhang, Meixia
Zeng, Shaoxue
Madigan, Michele C.
Zhang, Xinyuan
Gillies, Mark C.
Zhu, Ling
Zhang, Ting
author_facet Chen, Yingying
Coorey, Nathan J.
Zhang, Meixia
Zeng, Shaoxue
Madigan, Michele C.
Zhang, Xinyuan
Gillies, Mark C.
Zhu, Ling
Zhang, Ting
author_sort Chen, Yingying
collection PubMed
description The human retina, which is part of the central nervous system, has exceptionally high energy demands that requires an efficient metabolism of glucose, lipids, and amino acids. Dysregulation of retinal metabolism disrupts local energy supply and redox balance, contributing to the pathogenesis of diverse retinal diseases, including age-related macular degeneration, diabetic retinopathy, inherited retinal degenerations, and Macular Telangiectasia. A better understanding of the contribution of dysregulated metabolism to retinal diseases may provide better therapeutic targets than we currently have.
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spelling pubmed-91376842022-05-28 Metabolism Dysregulation in Retinal Diseases and Related Therapies Chen, Yingying Coorey, Nathan J. Zhang, Meixia Zeng, Shaoxue Madigan, Michele C. Zhang, Xinyuan Gillies, Mark C. Zhu, Ling Zhang, Ting Antioxidants (Basel) Review The human retina, which is part of the central nervous system, has exceptionally high energy demands that requires an efficient metabolism of glucose, lipids, and amino acids. Dysregulation of retinal metabolism disrupts local energy supply and redox balance, contributing to the pathogenesis of diverse retinal diseases, including age-related macular degeneration, diabetic retinopathy, inherited retinal degenerations, and Macular Telangiectasia. A better understanding of the contribution of dysregulated metabolism to retinal diseases may provide better therapeutic targets than we currently have. MDPI 2022-05-11 /pmc/articles/PMC9137684/ /pubmed/35624805 http://dx.doi.org/10.3390/antiox11050942 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Yingying
Coorey, Nathan J.
Zhang, Meixia
Zeng, Shaoxue
Madigan, Michele C.
Zhang, Xinyuan
Gillies, Mark C.
Zhu, Ling
Zhang, Ting
Metabolism Dysregulation in Retinal Diseases and Related Therapies
title Metabolism Dysregulation in Retinal Diseases and Related Therapies
title_full Metabolism Dysregulation in Retinal Diseases and Related Therapies
title_fullStr Metabolism Dysregulation in Retinal Diseases and Related Therapies
title_full_unstemmed Metabolism Dysregulation in Retinal Diseases and Related Therapies
title_short Metabolism Dysregulation in Retinal Diseases and Related Therapies
title_sort metabolism dysregulation in retinal diseases and related therapies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137684/
https://www.ncbi.nlm.nih.gov/pubmed/35624805
http://dx.doi.org/10.3390/antiox11050942
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