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Molecular Insights into Coumarin Analogues as Antimicrobial Agents: Recent Developments in Drug Discovery

SIMPLE SUMMARY: Coumarins are a large family of benzopyrones, and more than 1300 coumarins have been reported to date. Natural, as well as synthetic, coumarins have demonstrated a diverse activity spectrum. On the other hand, the demands of the current health scenario witnessing morbidity and mortal...

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Autores principales: Cheke, Rameshwar S., Patel, Harun M., Patil, Vaishali M., Ansari, Iqrar Ahmad, Ambhore, Jaya P., Shinde, Sachin D., Kadri, Adel, Snoussi, Mejdi, Adnan, Mohd, Kharkar, Prashant S., Pasupuleti, Visweswara Rao, Deshmukh, Prashant K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137837/
https://www.ncbi.nlm.nih.gov/pubmed/35625210
http://dx.doi.org/10.3390/antibiotics11050566
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author Cheke, Rameshwar S.
Patel, Harun M.
Patil, Vaishali M.
Ansari, Iqrar Ahmad
Ambhore, Jaya P.
Shinde, Sachin D.
Kadri, Adel
Snoussi, Mejdi
Adnan, Mohd
Kharkar, Prashant S.
Pasupuleti, Visweswara Rao
Deshmukh, Prashant K.
author_facet Cheke, Rameshwar S.
Patel, Harun M.
Patil, Vaishali M.
Ansari, Iqrar Ahmad
Ambhore, Jaya P.
Shinde, Sachin D.
Kadri, Adel
Snoussi, Mejdi
Adnan, Mohd
Kharkar, Prashant S.
Pasupuleti, Visweswara Rao
Deshmukh, Prashant K.
author_sort Cheke, Rameshwar S.
collection PubMed
description SIMPLE SUMMARY: Coumarins are a large family of benzopyrones, and more than 1300 coumarins have been reported to date. Natural, as well as synthetic, coumarins have demonstrated a diverse activity spectrum. On the other hand, the demands of the current health scenario witnessing morbidity and mortality due to microbial infections and multidrug-resistant bacterial strains, the well-reported phytochemical coumarin can be of interest. Some of the well-reported coumarin analogues as antimicrobial agents include β-lactum derivatives, coumarin-based 1,2,3-triazole compounds, the miconazole analogue, coumarin-substituted pyrazole hybrids, pyranocoumarin, coumarin−sulphonamide hybrids, pyranocoumarins, coumarin−sulphonamide derivatives, chromenylpyrazoles candidates, 3-amidocoumarins analogues, uracil−coumarin hybrids, indolinedione−coumarin hybrids, coumarin−imidazole hybrids, coumarin-fused pyrazolones and methyl thiazole derivatives, coumarin−theophylline hybrids, etc. In the present review, several methods for the synthesis of coumarin derivatives as antimicrobial agents are reported, along with structure−activity relationship (SAR) studies focusing on the developments reported since 2016. ABSTRACT: A major global health risk has been witnessed with the development of drug-resistant bacteria and multidrug-resistant pathogens linked to significant mortality. Coumarins are heterocyclic compounds belonging to the benzophenone class enriched in different plants. Coumarins and their derivatives have a wide range of biological activity, including antibacterial, anticoagulant, antioxidant, anti-inflammatory, antiviral, antitumour, and enzyme inhibitory effects. In the past few years, attempts have been reported towards the optimization, synthesis, and evaluation of novel coumarin analogues as antimicrobial agents. Several coumarin-based antibiotic hybrids have been developed, and the majority of them were reported to exhibit potential antibacterial effects. In the present work, studies reported from 2016 to 2020 about antimicrobial coumarin analogues are the focus. The diverse biological spectrum of coumarins can be attributed to their free radical scavenging abilities. In addition to various synthetic strategies developed, some of the structural features include a heterocyclic ring with electron-withdrawing/donating groups conjugated with the coumarin nucleus. The suggested structure−activity relationship (SAR) can provide insight into how coumarin hybrids can be rationally improved against multidrug-resistant bacteria. The present work demonstrates molecular insights for coumarin derivatives having antimicrobial properties from the recent past. The detailed SAR outcomes will benefit towards leading optimization during the discovery and development of novel antimicrobial therapeutics.
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spelling pubmed-91378372022-05-28 Molecular Insights into Coumarin Analogues as Antimicrobial Agents: Recent Developments in Drug Discovery Cheke, Rameshwar S. Patel, Harun M. Patil, Vaishali M. Ansari, Iqrar Ahmad Ambhore, Jaya P. Shinde, Sachin D. Kadri, Adel Snoussi, Mejdi Adnan, Mohd Kharkar, Prashant S. Pasupuleti, Visweswara Rao Deshmukh, Prashant K. Antibiotics (Basel) Review SIMPLE SUMMARY: Coumarins are a large family of benzopyrones, and more than 1300 coumarins have been reported to date. Natural, as well as synthetic, coumarins have demonstrated a diverse activity spectrum. On the other hand, the demands of the current health scenario witnessing morbidity and mortality due to microbial infections and multidrug-resistant bacterial strains, the well-reported phytochemical coumarin can be of interest. Some of the well-reported coumarin analogues as antimicrobial agents include β-lactum derivatives, coumarin-based 1,2,3-triazole compounds, the miconazole analogue, coumarin-substituted pyrazole hybrids, pyranocoumarin, coumarin−sulphonamide hybrids, pyranocoumarins, coumarin−sulphonamide derivatives, chromenylpyrazoles candidates, 3-amidocoumarins analogues, uracil−coumarin hybrids, indolinedione−coumarin hybrids, coumarin−imidazole hybrids, coumarin-fused pyrazolones and methyl thiazole derivatives, coumarin−theophylline hybrids, etc. In the present review, several methods for the synthesis of coumarin derivatives as antimicrobial agents are reported, along with structure−activity relationship (SAR) studies focusing on the developments reported since 2016. ABSTRACT: A major global health risk has been witnessed with the development of drug-resistant bacteria and multidrug-resistant pathogens linked to significant mortality. Coumarins are heterocyclic compounds belonging to the benzophenone class enriched in different plants. Coumarins and their derivatives have a wide range of biological activity, including antibacterial, anticoagulant, antioxidant, anti-inflammatory, antiviral, antitumour, and enzyme inhibitory effects. In the past few years, attempts have been reported towards the optimization, synthesis, and evaluation of novel coumarin analogues as antimicrobial agents. Several coumarin-based antibiotic hybrids have been developed, and the majority of them were reported to exhibit potential antibacterial effects. In the present work, studies reported from 2016 to 2020 about antimicrobial coumarin analogues are the focus. The diverse biological spectrum of coumarins can be attributed to their free radical scavenging abilities. In addition to various synthetic strategies developed, some of the structural features include a heterocyclic ring with electron-withdrawing/donating groups conjugated with the coumarin nucleus. The suggested structure−activity relationship (SAR) can provide insight into how coumarin hybrids can be rationally improved against multidrug-resistant bacteria. The present work demonstrates molecular insights for coumarin derivatives having antimicrobial properties from the recent past. The detailed SAR outcomes will benefit towards leading optimization during the discovery and development of novel antimicrobial therapeutics. MDPI 2022-04-24 /pmc/articles/PMC9137837/ /pubmed/35625210 http://dx.doi.org/10.3390/antibiotics11050566 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cheke, Rameshwar S.
Patel, Harun M.
Patil, Vaishali M.
Ansari, Iqrar Ahmad
Ambhore, Jaya P.
Shinde, Sachin D.
Kadri, Adel
Snoussi, Mejdi
Adnan, Mohd
Kharkar, Prashant S.
Pasupuleti, Visweswara Rao
Deshmukh, Prashant K.
Molecular Insights into Coumarin Analogues as Antimicrobial Agents: Recent Developments in Drug Discovery
title Molecular Insights into Coumarin Analogues as Antimicrobial Agents: Recent Developments in Drug Discovery
title_full Molecular Insights into Coumarin Analogues as Antimicrobial Agents: Recent Developments in Drug Discovery
title_fullStr Molecular Insights into Coumarin Analogues as Antimicrobial Agents: Recent Developments in Drug Discovery
title_full_unstemmed Molecular Insights into Coumarin Analogues as Antimicrobial Agents: Recent Developments in Drug Discovery
title_short Molecular Insights into Coumarin Analogues as Antimicrobial Agents: Recent Developments in Drug Discovery
title_sort molecular insights into coumarin analogues as antimicrobial agents: recent developments in drug discovery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137837/
https://www.ncbi.nlm.nih.gov/pubmed/35625210
http://dx.doi.org/10.3390/antibiotics11050566
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