Empagliflozin-Enhanced Antioxidant Defense Attenuates Lipotoxicity and Protects Hepatocytes by Promoting FoxO3a- and Nrf2-Mediated Nuclear Translocation via the CAMKK2/AMPK Pathway

Lipotoxicity is an important factor in the development and progression of nonalcoholic steatohepatitis. Excessive accumulation of saturated fatty acids can increase the substrates of the mitochondrial electron transport chain in hepatocytes and cause the generation of reactive oxygen species, result...

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Detalles Bibliográficos
Autores principales: Wang, Yangyang, Ding, Yipei, Sun, Pengbo, Zhang, Wanqiu, Xin, Qilei, Wang, Ningchao, Niu, Yaoyun, Chen, Yang, Luo, Jingyi, Lu, Jinghua, Zhou, Jin, Xu, Naihan, Zhang, Yaou, Xie, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137911/
https://www.ncbi.nlm.nih.gov/pubmed/35624663
http://dx.doi.org/10.3390/antiox11050799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137911/
https://www.ncbi.nlm.nih.gov/pubmed/35624663
http://dx.doi.org/10.3390/antiox11050799

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