Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy

Ivermectin (IVM) could cause potential neurotoxicity; however, the precise molecular mechanisms remain unclear. This study explores the cytotoxicity of IVM in human neuroblastoma (SH-SY5Y) cells and the underlying molecular mechanisms. The results show that IVM treatment (2.5–15 μM) for 24 h could i...

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Detalles Bibliográficos
Autores principales: Zhang, Yuan, Sun, Tun, Li, Meng, Lin, Yanling, Liu, Yue, Tang, Shusheng, Dai, Chongshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137967/
https://www.ncbi.nlm.nih.gov/pubmed/35624772
http://dx.doi.org/10.3390/antiox11050908

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