Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle

Erythroid-related nuclear factor 2 (NRF2) and the antioxidant-responsive-elements (ARE) signaling pathway are the master regulators of cell antioxidant defenses, playing a key role in maintaining cellular homeostasis, a scenario in which proper mitochondrial function is essential. Increasing evidenc...

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Detalles Bibliográficos
Autores principales: Souza, Jennyffer, da Silva, Rodrigo Augusto, da Luz Scheffer, Débora, Penteado, Rafael, Solano, Alexandre, Barros, Leonardo, Budde, Henning, Trostchansky, Andrés, Latini, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138070/
https://www.ncbi.nlm.nih.gov/pubmed/35624690
http://dx.doi.org/10.3390/antiox11050826
Descripción
Sumario:Erythroid-related nuclear factor 2 (NRF2) and the antioxidant-responsive-elements (ARE) signaling pathway are the master regulators of cell antioxidant defenses, playing a key role in maintaining cellular homeostasis, a scenario in which proper mitochondrial function is essential. Increasing evidence indicates that the regular practice of physical exercise increases cellular antioxidant defenses by activating NRF2 signaling. This manuscript reviewed classic and ongoing research on the beneficial effects of exercise on the antioxidant system in both the brain and skeletal muscle.

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