Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle

Erythroid-related nuclear factor 2 (NRF2) and the antioxidant-responsive-elements (ARE) signaling pathway are the master regulators of cell antioxidant defenses, playing a key role in maintaining cellular homeostasis, a scenario in which proper mitochondrial function is essential. Increasing evidenc...

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Autores principales: Souza, Jennyffer, da Silva, Rodrigo Augusto, da Luz Scheffer, Débora, Penteado, Rafael, Solano, Alexandre, Barros, Leonardo, Budde, Henning, Trostchansky, Andrés, Latini, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138070/
https://www.ncbi.nlm.nih.gov/pubmed/35624690
http://dx.doi.org/10.3390/antiox11050826
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author Souza, Jennyffer
da Silva, Rodrigo Augusto
da Luz Scheffer, Débora
Penteado, Rafael
Solano, Alexandre
Barros, Leonardo
Budde, Henning
Trostchansky, Andrés
Latini, Alexandra
author_facet Souza, Jennyffer
da Silva, Rodrigo Augusto
da Luz Scheffer, Débora
Penteado, Rafael
Solano, Alexandre
Barros, Leonardo
Budde, Henning
Trostchansky, Andrés
Latini, Alexandra
author_sort Souza, Jennyffer
collection PubMed
description Erythroid-related nuclear factor 2 (NRF2) and the antioxidant-responsive-elements (ARE) signaling pathway are the master regulators of cell antioxidant defenses, playing a key role in maintaining cellular homeostasis, a scenario in which proper mitochondrial function is essential. Increasing evidence indicates that the regular practice of physical exercise increases cellular antioxidant defenses by activating NRF2 signaling. This manuscript reviewed classic and ongoing research on the beneficial effects of exercise on the antioxidant system in both the brain and skeletal muscle.
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spelling pubmed-91380702022-05-28 Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle Souza, Jennyffer da Silva, Rodrigo Augusto da Luz Scheffer, Débora Penteado, Rafael Solano, Alexandre Barros, Leonardo Budde, Henning Trostchansky, Andrés Latini, Alexandra Antioxidants (Basel) Review Erythroid-related nuclear factor 2 (NRF2) and the antioxidant-responsive-elements (ARE) signaling pathway are the master regulators of cell antioxidant defenses, playing a key role in maintaining cellular homeostasis, a scenario in which proper mitochondrial function is essential. Increasing evidence indicates that the regular practice of physical exercise increases cellular antioxidant defenses by activating NRF2 signaling. This manuscript reviewed classic and ongoing research on the beneficial effects of exercise on the antioxidant system in both the brain and skeletal muscle. MDPI 2022-04-23 /pmc/articles/PMC9138070/ /pubmed/35624690 http://dx.doi.org/10.3390/antiox11050826 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Souza, Jennyffer
da Silva, Rodrigo Augusto
da Luz Scheffer, Débora
Penteado, Rafael
Solano, Alexandre
Barros, Leonardo
Budde, Henning
Trostchansky, Andrés
Latini, Alexandra
Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle
title Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle
title_full Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle
title_fullStr Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle
title_full_unstemmed Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle
title_short Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle
title_sort physical-exercise-induced antioxidant effects on the brain and skeletal muscle
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138070/
https://www.ncbi.nlm.nih.gov/pubmed/35624690
http://dx.doi.org/10.3390/antiox11050826
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