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Applications of Photodynamic Therapy in Endometrial Diseases
Photodynamic therapy (PDT) is a medical procedure useful for several benign conditions (such as wound healing and infections) and cancer. PDT is minimally invasive, presents few side effects, good scaring, and is able to minimal tissue destruction maintaining organ anatomy and function. Endoscopic a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138084/ https://www.ncbi.nlm.nih.gov/pubmed/35621504 http://dx.doi.org/10.3390/bioengineering9050226 |
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author | Correia-Barros, Gabriela Serambeque, Beatriz Carvalho, Maria João Marto, Carlos Miguel Pineiro, Marta Pinho e Melo, Teresa M. V. D. Botelho, Maria Filomena Laranjo, Mafalda |
author_facet | Correia-Barros, Gabriela Serambeque, Beatriz Carvalho, Maria João Marto, Carlos Miguel Pineiro, Marta Pinho e Melo, Teresa M. V. D. Botelho, Maria Filomena Laranjo, Mafalda |
author_sort | Correia-Barros, Gabriela |
collection | PubMed |
description | Photodynamic therapy (PDT) is a medical procedure useful for several benign conditions (such as wound healing and infections) and cancer. PDT is minimally invasive, presents few side effects, good scaring, and is able to minimal tissue destruction maintaining organ anatomy and function. Endoscopic access to the uterus puts PDT in the spotlight for endometrial disease treatment. This work systematically reviews the current evidence of PDT’s potential and usefulness in endometrial diseases. Thus, this narrative review focused on PDT applications for endometrial disease, including reports regarding in vitro, ex vivo, animal, and clinical studies. Cell lines and primary samples were used as in vitro models of cancer, adenomyosis and endometrioses, while most animal studies focused the PDT outcomes on endometrial ablation. A few clinical attempts are known using PDT for endometrial ablation and cancer lesions. This review emphasises PDT as a promising field of research. This therapeutic approach has the potential to become an effective conservative treatment method for endometrial benign and malignant lesions. Further investigations with improved photosensitisers are highly expected. |
format | Online Article Text |
id | pubmed-9138084 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91380842022-05-28 Applications of Photodynamic Therapy in Endometrial Diseases Correia-Barros, Gabriela Serambeque, Beatriz Carvalho, Maria João Marto, Carlos Miguel Pineiro, Marta Pinho e Melo, Teresa M. V. D. Botelho, Maria Filomena Laranjo, Mafalda Bioengineering (Basel) Review Photodynamic therapy (PDT) is a medical procedure useful for several benign conditions (such as wound healing and infections) and cancer. PDT is minimally invasive, presents few side effects, good scaring, and is able to minimal tissue destruction maintaining organ anatomy and function. Endoscopic access to the uterus puts PDT in the spotlight for endometrial disease treatment. This work systematically reviews the current evidence of PDT’s potential and usefulness in endometrial diseases. Thus, this narrative review focused on PDT applications for endometrial disease, including reports regarding in vitro, ex vivo, animal, and clinical studies. Cell lines and primary samples were used as in vitro models of cancer, adenomyosis and endometrioses, while most animal studies focused the PDT outcomes on endometrial ablation. A few clinical attempts are known using PDT for endometrial ablation and cancer lesions. This review emphasises PDT as a promising field of research. This therapeutic approach has the potential to become an effective conservative treatment method for endometrial benign and malignant lesions. Further investigations with improved photosensitisers are highly expected. MDPI 2022-05-23 /pmc/articles/PMC9138084/ /pubmed/35621504 http://dx.doi.org/10.3390/bioengineering9050226 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Correia-Barros, Gabriela Serambeque, Beatriz Carvalho, Maria João Marto, Carlos Miguel Pineiro, Marta Pinho e Melo, Teresa M. V. D. Botelho, Maria Filomena Laranjo, Mafalda Applications of Photodynamic Therapy in Endometrial Diseases |
title | Applications of Photodynamic Therapy in Endometrial Diseases |
title_full | Applications of Photodynamic Therapy in Endometrial Diseases |
title_fullStr | Applications of Photodynamic Therapy in Endometrial Diseases |
title_full_unstemmed | Applications of Photodynamic Therapy in Endometrial Diseases |
title_short | Applications of Photodynamic Therapy in Endometrial Diseases |
title_sort | applications of photodynamic therapy in endometrial diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138084/ https://www.ncbi.nlm.nih.gov/pubmed/35621504 http://dx.doi.org/10.3390/bioengineering9050226 |
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