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An Observational Study of MDR Hospital-Acquired Infections and Antibiotic Use during COVID-19 Pandemic: A Call for Antimicrobial Stewardship Programs

The pandemic caused by the COVID-19 virus has required major adjustments to healthcare systems, especially to infection control and antimicrobial stewardship. The objective of this study was to describe the incidence of multidrug-resistant (MDR) hospital-acquired infections (HAIs) and antibiotic con...

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Autores principales: Shbaklo, Nour, Corcione, Silvia, Vicentini, Costanza, Giordano, Susanna, Fiorentino, Denise, Bianco, Gabriele, Cattel, Francesco, Cavallo, Rossana, Zotti, Carla Maria, De Rosa, Francesco Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138124/
https://www.ncbi.nlm.nih.gov/pubmed/35625339
http://dx.doi.org/10.3390/antibiotics11050695
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author Shbaklo, Nour
Corcione, Silvia
Vicentini, Costanza
Giordano, Susanna
Fiorentino, Denise
Bianco, Gabriele
Cattel, Francesco
Cavallo, Rossana
Zotti, Carla Maria
De Rosa, Francesco Giuseppe
author_facet Shbaklo, Nour
Corcione, Silvia
Vicentini, Costanza
Giordano, Susanna
Fiorentino, Denise
Bianco, Gabriele
Cattel, Francesco
Cavallo, Rossana
Zotti, Carla Maria
De Rosa, Francesco Giuseppe
author_sort Shbaklo, Nour
collection PubMed
description The pandemic caused by the COVID-19 virus has required major adjustments to healthcare systems, especially to infection control and antimicrobial stewardship. The objective of this study was to describe the incidence of multidrug-resistant (MDR) hospital-acquired infections (HAIs) and antibiotic consumption during the three waves of COVID-19 and to compare it to the period before the outbreak at Molinette Hospital, located in the City of Health and Sciences, a 1200-bed teaching hospital with surgical, medical, and intensive care units. We demonstrated an increase in MDR infections: particularly in K. pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp), A. baumannii, and MRSA. Fluoroquinolone use showed a significant increasing trend in the pre-COVID period but saw a significant reduction in the COVID period. The use of fourth- and fifth-generation cephalosporins and piperacillin–tazobactam increased at the beginning of the COVID period. Our findings support the need for restoring stewardship and infection control practices, specifically source control, hygiene, and management of invasive devices. In addition, our data reveal the need for improved microbiological diagnosis to guide appropriate treatment and prompt infection control during pandemics. Despite the infection control practices in place during the COVID-19 pandemic, invasive procedures in critically ill patients and poor source control still increase the risk of HAIs caused by MDR organisms.
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spelling pubmed-91381242022-05-28 An Observational Study of MDR Hospital-Acquired Infections and Antibiotic Use during COVID-19 Pandemic: A Call for Antimicrobial Stewardship Programs Shbaklo, Nour Corcione, Silvia Vicentini, Costanza Giordano, Susanna Fiorentino, Denise Bianco, Gabriele Cattel, Francesco Cavallo, Rossana Zotti, Carla Maria De Rosa, Francesco Giuseppe Antibiotics (Basel) Article The pandemic caused by the COVID-19 virus has required major adjustments to healthcare systems, especially to infection control and antimicrobial stewardship. The objective of this study was to describe the incidence of multidrug-resistant (MDR) hospital-acquired infections (HAIs) and antibiotic consumption during the three waves of COVID-19 and to compare it to the period before the outbreak at Molinette Hospital, located in the City of Health and Sciences, a 1200-bed teaching hospital with surgical, medical, and intensive care units. We demonstrated an increase in MDR infections: particularly in K. pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp), A. baumannii, and MRSA. Fluoroquinolone use showed a significant increasing trend in the pre-COVID period but saw a significant reduction in the COVID period. The use of fourth- and fifth-generation cephalosporins and piperacillin–tazobactam increased at the beginning of the COVID period. Our findings support the need for restoring stewardship and infection control practices, specifically source control, hygiene, and management of invasive devices. In addition, our data reveal the need for improved microbiological diagnosis to guide appropriate treatment and prompt infection control during pandemics. Despite the infection control practices in place during the COVID-19 pandemic, invasive procedures in critically ill patients and poor source control still increase the risk of HAIs caused by MDR organisms. MDPI 2022-05-20 /pmc/articles/PMC9138124/ /pubmed/35625339 http://dx.doi.org/10.3390/antibiotics11050695 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shbaklo, Nour
Corcione, Silvia
Vicentini, Costanza
Giordano, Susanna
Fiorentino, Denise
Bianco, Gabriele
Cattel, Francesco
Cavallo, Rossana
Zotti, Carla Maria
De Rosa, Francesco Giuseppe
An Observational Study of MDR Hospital-Acquired Infections and Antibiotic Use during COVID-19 Pandemic: A Call for Antimicrobial Stewardship Programs
title An Observational Study of MDR Hospital-Acquired Infections and Antibiotic Use during COVID-19 Pandemic: A Call for Antimicrobial Stewardship Programs
title_full An Observational Study of MDR Hospital-Acquired Infections and Antibiotic Use during COVID-19 Pandemic: A Call for Antimicrobial Stewardship Programs
title_fullStr An Observational Study of MDR Hospital-Acquired Infections and Antibiotic Use during COVID-19 Pandemic: A Call for Antimicrobial Stewardship Programs
title_full_unstemmed An Observational Study of MDR Hospital-Acquired Infections and Antibiotic Use during COVID-19 Pandemic: A Call for Antimicrobial Stewardship Programs
title_short An Observational Study of MDR Hospital-Acquired Infections and Antibiotic Use during COVID-19 Pandemic: A Call for Antimicrobial Stewardship Programs
title_sort observational study of mdr hospital-acquired infections and antibiotic use during covid-19 pandemic: a call for antimicrobial stewardship programs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138124/
https://www.ncbi.nlm.nih.gov/pubmed/35625339
http://dx.doi.org/10.3390/antibiotics11050695
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