Ceftazidime–Avibactam in Combination with Imipenem as Salvage Therapy for ST11 KPC-33-Producing Klebsiella pneumoniae

A 22-year-old man, after a hematopoietic stem cell transplant, suffered long-term pneumonia caused by bla(KPC-2)-positive K. pneumoniae and bla(KPC-33-)positive K. pneumoniae alternately and finally achieved pathogenic clearance and improvement of clinical infectious conditions after using ceftazidi...

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Detalles Bibliográficos
Autores principales: Ding, Li, Shen, Siquan, Han, Renru, Yin, Dandan, Guo, Yan, Hu, Fupin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138154/
https://www.ncbi.nlm.nih.gov/pubmed/35625247
http://dx.doi.org/10.3390/antibiotics11050604
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author Ding, Li
Shen, Siquan
Han, Renru
Yin, Dandan
Guo, Yan
Hu, Fupin
author_facet Ding, Li
Shen, Siquan
Han, Renru
Yin, Dandan
Guo, Yan
Hu, Fupin
author_sort Ding, Li
collection PubMed
description A 22-year-old man, after a hematopoietic stem cell transplant, suffered long-term pneumonia caused by bla(KPC-2)-positive K. pneumoniae and bla(KPC-33-)positive K. pneumoniae alternately and finally achieved pathogenic clearance and improvement of clinical infectious conditions after using ceftazidime–avibactam in combination with imipenem as salvage therapy. This case provides a reference for treating infection caused by K. pneumoniae with a KPC variant in countries lacking new antimicrobial agents.
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spelling pubmed-91381542022-05-28 Ceftazidime–Avibactam in Combination with Imipenem as Salvage Therapy for ST11 KPC-33-Producing Klebsiella pneumoniae Ding, Li Shen, Siquan Han, Renru Yin, Dandan Guo, Yan Hu, Fupin Antibiotics (Basel) Case Report A 22-year-old man, after a hematopoietic stem cell transplant, suffered long-term pneumonia caused by bla(KPC-2)-positive K. pneumoniae and bla(KPC-33-)positive K. pneumoniae alternately and finally achieved pathogenic clearance and improvement of clinical infectious conditions after using ceftazidime–avibactam in combination with imipenem as salvage therapy. This case provides a reference for treating infection caused by K. pneumoniae with a KPC variant in countries lacking new antimicrobial agents. MDPI 2022-04-29 /pmc/articles/PMC9138154/ /pubmed/35625247 http://dx.doi.org/10.3390/antibiotics11050604 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Ding, Li
Shen, Siquan
Han, Renru
Yin, Dandan
Guo, Yan
Hu, Fupin
Ceftazidime–Avibactam in Combination with Imipenem as Salvage Therapy for ST11 KPC-33-Producing Klebsiella pneumoniae
title Ceftazidime–Avibactam in Combination with Imipenem as Salvage Therapy for ST11 KPC-33-Producing Klebsiella pneumoniae
title_full Ceftazidime–Avibactam in Combination with Imipenem as Salvage Therapy for ST11 KPC-33-Producing Klebsiella pneumoniae
title_fullStr Ceftazidime–Avibactam in Combination with Imipenem as Salvage Therapy for ST11 KPC-33-Producing Klebsiella pneumoniae
title_full_unstemmed Ceftazidime–Avibactam in Combination with Imipenem as Salvage Therapy for ST11 KPC-33-Producing Klebsiella pneumoniae
title_short Ceftazidime–Avibactam in Combination with Imipenem as Salvage Therapy for ST11 KPC-33-Producing Klebsiella pneumoniae
title_sort ceftazidime–avibactam in combination with imipenem as salvage therapy for st11 kpc-33-producing klebsiella pneumoniae
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138154/
https://www.ncbi.nlm.nih.gov/pubmed/35625247
http://dx.doi.org/10.3390/antibiotics11050604
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