Cargando…
Heracleum persicum Essential Oil Nanoemulsion: A Nanocarrier System for the Delivery of Promising Anticancer and Antioxidant Bioactive Agents
Essential oils are important compounds for the prevention and/or treatment of various diseases in which solubility and bio-accessibility can be improved by nanoemulsion systems. Heracleum persicum oil nanoemulsion (HAE-NE) was prepared and biological properties were investigated against human breast...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138159/ https://www.ncbi.nlm.nih.gov/pubmed/35624695 http://dx.doi.org/10.3390/antiox11050831 |
_version_ | 1784714556923183104 |
---|---|
author | Bashlouei, Shima Ghareh Karimi, Ehsan Zareian, Mohsen Oskoueian, Ehsan Shakeri, Majid |
author_facet | Bashlouei, Shima Ghareh Karimi, Ehsan Zareian, Mohsen Oskoueian, Ehsan Shakeri, Majid |
author_sort | Bashlouei, Shima Ghareh |
collection | PubMed |
description | Essential oils are important compounds for the prevention and/or treatment of various diseases in which solubility and bio-accessibility can be improved by nanoemulsion systems. Heracleum persicum oil nanoemulsion (HAE-NE) was prepared and biological properties were investigated against human breast cancer cells and normal human fibroblasts foreskin. Particle size, zeta potential and poly dispersity index were 153 nm, −47.9 mV and 0.35, respectively. (E)anethole (57.9%), terpinolene (13.8%), ɣ-terpinene (8.1%), myrcene (6.8%), hexyl butyrate (5.2%), octyl butanoate (4.5%) and octyl acetate (3.7%) was detected in nanoemulsion. Proliferation of cancer cells at IC(50) = 2.32 μg/mL was significantly (p < 0.05) inhibited, and cell migration occurred at 1.5 μL/mL. The HAE-NE at 1.5, 2.5 and 3.5 µg/concentration up-regulated caspase 3 and enhanced sub-G1 peak of cell cycle with nil cytotoxic effects in the liver, kidney and jejunum of mice. Villus height, villus width, crypt depth and goblet cells in mice group fed with 10 and 20 mg/kg body weight of HAE-NE improved. Cellular redox state in the liver indicated 10 and 20 mg/kg body weight of nanoemulsion significantly up-regulated the expression of SOD, CAT and GPx genes. Heracleum persicum oil nanoemulsion could be an eco-friendly nanotherapeutic option for pharmaceutical, cosmetological and food applications. |
format | Online Article Text |
id | pubmed-9138159 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91381592022-05-28 Heracleum persicum Essential Oil Nanoemulsion: A Nanocarrier System for the Delivery of Promising Anticancer and Antioxidant Bioactive Agents Bashlouei, Shima Ghareh Karimi, Ehsan Zareian, Mohsen Oskoueian, Ehsan Shakeri, Majid Antioxidants (Basel) Article Essential oils are important compounds for the prevention and/or treatment of various diseases in which solubility and bio-accessibility can be improved by nanoemulsion systems. Heracleum persicum oil nanoemulsion (HAE-NE) was prepared and biological properties were investigated against human breast cancer cells and normal human fibroblasts foreskin. Particle size, zeta potential and poly dispersity index were 153 nm, −47.9 mV and 0.35, respectively. (E)anethole (57.9%), terpinolene (13.8%), ɣ-terpinene (8.1%), myrcene (6.8%), hexyl butyrate (5.2%), octyl butanoate (4.5%) and octyl acetate (3.7%) was detected in nanoemulsion. Proliferation of cancer cells at IC(50) = 2.32 μg/mL was significantly (p < 0.05) inhibited, and cell migration occurred at 1.5 μL/mL. The HAE-NE at 1.5, 2.5 and 3.5 µg/concentration up-regulated caspase 3 and enhanced sub-G1 peak of cell cycle with nil cytotoxic effects in the liver, kidney and jejunum of mice. Villus height, villus width, crypt depth and goblet cells in mice group fed with 10 and 20 mg/kg body weight of HAE-NE improved. Cellular redox state in the liver indicated 10 and 20 mg/kg body weight of nanoemulsion significantly up-regulated the expression of SOD, CAT and GPx genes. Heracleum persicum oil nanoemulsion could be an eco-friendly nanotherapeutic option for pharmaceutical, cosmetological and food applications. MDPI 2022-04-25 /pmc/articles/PMC9138159/ /pubmed/35624695 http://dx.doi.org/10.3390/antiox11050831 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bashlouei, Shima Ghareh Karimi, Ehsan Zareian, Mohsen Oskoueian, Ehsan Shakeri, Majid Heracleum persicum Essential Oil Nanoemulsion: A Nanocarrier System for the Delivery of Promising Anticancer and Antioxidant Bioactive Agents |
title | Heracleum persicum Essential Oil Nanoemulsion: A Nanocarrier System for the Delivery of Promising Anticancer and Antioxidant Bioactive Agents |
title_full | Heracleum persicum Essential Oil Nanoemulsion: A Nanocarrier System for the Delivery of Promising Anticancer and Antioxidant Bioactive Agents |
title_fullStr | Heracleum persicum Essential Oil Nanoemulsion: A Nanocarrier System for the Delivery of Promising Anticancer and Antioxidant Bioactive Agents |
title_full_unstemmed | Heracleum persicum Essential Oil Nanoemulsion: A Nanocarrier System for the Delivery of Promising Anticancer and Antioxidant Bioactive Agents |
title_short | Heracleum persicum Essential Oil Nanoemulsion: A Nanocarrier System for the Delivery of Promising Anticancer and Antioxidant Bioactive Agents |
title_sort | heracleum persicum essential oil nanoemulsion: a nanocarrier system for the delivery of promising anticancer and antioxidant bioactive agents |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138159/ https://www.ncbi.nlm.nih.gov/pubmed/35624695 http://dx.doi.org/10.3390/antiox11050831 |
work_keys_str_mv | AT bashloueishimaghareh heracleumpersicumessentialoilnanoemulsionananocarriersystemforthedeliveryofpromisinganticancerandantioxidantbioactiveagents AT karimiehsan heracleumpersicumessentialoilnanoemulsionananocarriersystemforthedeliveryofpromisinganticancerandantioxidantbioactiveagents AT zareianmohsen heracleumpersicumessentialoilnanoemulsionananocarriersystemforthedeliveryofpromisinganticancerandantioxidantbioactiveagents AT oskoueianehsan heracleumpersicumessentialoilnanoemulsionananocarriersystemforthedeliveryofpromisinganticancerandantioxidantbioactiveagents AT shakerimajid heracleumpersicumessentialoilnanoemulsionananocarriersystemforthedeliveryofpromisinganticancerandantioxidantbioactiveagents |