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Vascular Endothelial Growth Factor as a Potential Biomarker of Neuroinflammation and Frontal Cognitive Impairment in Patients with Alcohol Use Disorder

(1) Background: Alcohol Use Disorder (AUD) is associated with functional disruption of several brain structures that may trigger cognitive dysfunction. One of the mechanisms of alcohol-associated cognitive impairment has been proposed to arise from its direct impact on the immune system, which culmi...

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Autores principales: Requena-Ocaña, Nerea, Flores-Lopez, María, Papaseit, Esther, García-Marchena, Nuria, Ruiz, Juan Jesús, Ortega-Pinazo, Jesús, Serrano, Antonia, Pavón-Morón, Francisco Javier, Farré, Magí, Suarez, Juan, Rodríguez de Fonseca, Fernando, Araos, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138236/
https://www.ncbi.nlm.nih.gov/pubmed/35625687
http://dx.doi.org/10.3390/biomedicines10050947
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author Requena-Ocaña, Nerea
Flores-Lopez, María
Papaseit, Esther
García-Marchena, Nuria
Ruiz, Juan Jesús
Ortega-Pinazo, Jesús
Serrano, Antonia
Pavón-Morón, Francisco Javier
Farré, Magí
Suarez, Juan
Rodríguez de Fonseca, Fernando
Araos, Pedro
author_facet Requena-Ocaña, Nerea
Flores-Lopez, María
Papaseit, Esther
García-Marchena, Nuria
Ruiz, Juan Jesús
Ortega-Pinazo, Jesús
Serrano, Antonia
Pavón-Morón, Francisco Javier
Farré, Magí
Suarez, Juan
Rodríguez de Fonseca, Fernando
Araos, Pedro
author_sort Requena-Ocaña, Nerea
collection PubMed
description (1) Background: Alcohol Use Disorder (AUD) is associated with functional disruption of several brain structures that may trigger cognitive dysfunction. One of the mechanisms of alcohol-associated cognitive impairment has been proposed to arise from its direct impact on the immune system, which culminates in the release of cytokines and chemokines which can eventually reach the brain. Alcohol can also disrupt the blood–brain barrier, facilitating the penetration of pro-inflammatory molecules throughout vascular endothelial growth factor A (VEGFA). Thus, alcohol-induced alterations in chemokines and VEGFA might contribute to the neuroinflammation and cognitive impairment associated with AUD. (2) Methods: The present cross-sectional study investigates whether patients with AUD (n = 86) present cognitive disability associated to alterations in plasma concentration of SDF-1, fractalkine, eotaxin, MCP-1, MIP-1α and VEGFA when compared to control subjects (n = 51). (3) Results: The analysis indicated that SDF-1 and MCP-1 concentrations were higher in AUD patients than in controls. Concentrations of VEGFA were higher in AUD patients with severe frontal deficits, and the score of frontal lobe functions was negatively correlated with VEGFA and fractalkine. Acute alcohol effects on VEGFA plasma levels in healthy volunteers demonstrated the induction of VEGFA release by heavy alcohol drinking. VEGFA was positively correlated with pro-inflammatory chemokines in AUD patients with frontal cognitive impairment. (4) Conclusions: we propose VEGFA/chemokine monitoring as biomarkers of potential cognitive impairment in AUD patients.
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spelling pubmed-91382362022-05-28 Vascular Endothelial Growth Factor as a Potential Biomarker of Neuroinflammation and Frontal Cognitive Impairment in Patients with Alcohol Use Disorder Requena-Ocaña, Nerea Flores-Lopez, María Papaseit, Esther García-Marchena, Nuria Ruiz, Juan Jesús Ortega-Pinazo, Jesús Serrano, Antonia Pavón-Morón, Francisco Javier Farré, Magí Suarez, Juan Rodríguez de Fonseca, Fernando Araos, Pedro Biomedicines Article (1) Background: Alcohol Use Disorder (AUD) is associated with functional disruption of several brain structures that may trigger cognitive dysfunction. One of the mechanisms of alcohol-associated cognitive impairment has been proposed to arise from its direct impact on the immune system, which culminates in the release of cytokines and chemokines which can eventually reach the brain. Alcohol can also disrupt the blood–brain barrier, facilitating the penetration of pro-inflammatory molecules throughout vascular endothelial growth factor A (VEGFA). Thus, alcohol-induced alterations in chemokines and VEGFA might contribute to the neuroinflammation and cognitive impairment associated with AUD. (2) Methods: The present cross-sectional study investigates whether patients with AUD (n = 86) present cognitive disability associated to alterations in plasma concentration of SDF-1, fractalkine, eotaxin, MCP-1, MIP-1α and VEGFA when compared to control subjects (n = 51). (3) Results: The analysis indicated that SDF-1 and MCP-1 concentrations were higher in AUD patients than in controls. Concentrations of VEGFA were higher in AUD patients with severe frontal deficits, and the score of frontal lobe functions was negatively correlated with VEGFA and fractalkine. Acute alcohol effects on VEGFA plasma levels in healthy volunteers demonstrated the induction of VEGFA release by heavy alcohol drinking. VEGFA was positively correlated with pro-inflammatory chemokines in AUD patients with frontal cognitive impairment. (4) Conclusions: we propose VEGFA/chemokine monitoring as biomarkers of potential cognitive impairment in AUD patients. MDPI 2022-04-20 /pmc/articles/PMC9138236/ /pubmed/35625687 http://dx.doi.org/10.3390/biomedicines10050947 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Requena-Ocaña, Nerea
Flores-Lopez, María
Papaseit, Esther
García-Marchena, Nuria
Ruiz, Juan Jesús
Ortega-Pinazo, Jesús
Serrano, Antonia
Pavón-Morón, Francisco Javier
Farré, Magí
Suarez, Juan
Rodríguez de Fonseca, Fernando
Araos, Pedro
Vascular Endothelial Growth Factor as a Potential Biomarker of Neuroinflammation and Frontal Cognitive Impairment in Patients with Alcohol Use Disorder
title Vascular Endothelial Growth Factor as a Potential Biomarker of Neuroinflammation and Frontal Cognitive Impairment in Patients with Alcohol Use Disorder
title_full Vascular Endothelial Growth Factor as a Potential Biomarker of Neuroinflammation and Frontal Cognitive Impairment in Patients with Alcohol Use Disorder
title_fullStr Vascular Endothelial Growth Factor as a Potential Biomarker of Neuroinflammation and Frontal Cognitive Impairment in Patients with Alcohol Use Disorder
title_full_unstemmed Vascular Endothelial Growth Factor as a Potential Biomarker of Neuroinflammation and Frontal Cognitive Impairment in Patients with Alcohol Use Disorder
title_short Vascular Endothelial Growth Factor as a Potential Biomarker of Neuroinflammation and Frontal Cognitive Impairment in Patients with Alcohol Use Disorder
title_sort vascular endothelial growth factor as a potential biomarker of neuroinflammation and frontal cognitive impairment in patients with alcohol use disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138236/
https://www.ncbi.nlm.nih.gov/pubmed/35625687
http://dx.doi.org/10.3390/biomedicines10050947
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