COVID-19 and the Brain: The Neuropathological Italian Experience on 33 Adult Autopsies

Neurological symptoms are increasingly recognized in SARS-CoV-2 infected individuals. However, the neuropathogenesis remains unclear and it is not possible to define a specific damage pattern due to brain virus infection. In the present study, 33 cases of brain autopsies performed during the first (...

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Autores principales: Fabbri, Viscardo P., Riefolo, Mattia, Lazzarotto, Tiziana, Gabrielli, Liliana, Cenacchi, Giovanna, Gallo, Carmine, Aspide, Raffaele, Frascaroli, Guido, Liguori, Rocco, Lodi, Raffaele, Tonon, Caterina, D’Errico, Antonietta, Foschini, Maria Pia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138268/
https://www.ncbi.nlm.nih.gov/pubmed/35625558
http://dx.doi.org/10.3390/biom12050629
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author Fabbri, Viscardo P.
Riefolo, Mattia
Lazzarotto, Tiziana
Gabrielli, Liliana
Cenacchi, Giovanna
Gallo, Carmine
Aspide, Raffaele
Frascaroli, Guido
Liguori, Rocco
Lodi, Raffaele
Tonon, Caterina
D’Errico, Antonietta
Foschini, Maria Pia
author_facet Fabbri, Viscardo P.
Riefolo, Mattia
Lazzarotto, Tiziana
Gabrielli, Liliana
Cenacchi, Giovanna
Gallo, Carmine
Aspide, Raffaele
Frascaroli, Guido
Liguori, Rocco
Lodi, Raffaele
Tonon, Caterina
D’Errico, Antonietta
Foschini, Maria Pia
author_sort Fabbri, Viscardo P.
collection PubMed
description Neurological symptoms are increasingly recognized in SARS-CoV-2 infected individuals. However, the neuropathogenesis remains unclear and it is not possible to define a specific damage pattern due to brain virus infection. In the present study, 33 cases of brain autopsies performed during the first (February–April 2020) and the second/third (November 2020–April 2021) pandemic waves are described. In all the cases, SARS-CoV-2 RNA was searched. Pathological findings are described and compared with those presently published.
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spelling pubmed-91382682022-05-28 COVID-19 and the Brain: The Neuropathological Italian Experience on 33 Adult Autopsies Fabbri, Viscardo P. Riefolo, Mattia Lazzarotto, Tiziana Gabrielli, Liliana Cenacchi, Giovanna Gallo, Carmine Aspide, Raffaele Frascaroli, Guido Liguori, Rocco Lodi, Raffaele Tonon, Caterina D’Errico, Antonietta Foschini, Maria Pia Biomolecules Article Neurological symptoms are increasingly recognized in SARS-CoV-2 infected individuals. However, the neuropathogenesis remains unclear and it is not possible to define a specific damage pattern due to brain virus infection. In the present study, 33 cases of brain autopsies performed during the first (February–April 2020) and the second/third (November 2020–April 2021) pandemic waves are described. In all the cases, SARS-CoV-2 RNA was searched. Pathological findings are described and compared with those presently published. MDPI 2022-04-25 /pmc/articles/PMC9138268/ /pubmed/35625558 http://dx.doi.org/10.3390/biom12050629 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fabbri, Viscardo P.
Riefolo, Mattia
Lazzarotto, Tiziana
Gabrielli, Liliana
Cenacchi, Giovanna
Gallo, Carmine
Aspide, Raffaele
Frascaroli, Guido
Liguori, Rocco
Lodi, Raffaele
Tonon, Caterina
D’Errico, Antonietta
Foschini, Maria Pia
COVID-19 and the Brain: The Neuropathological Italian Experience on 33 Adult Autopsies
title COVID-19 and the Brain: The Neuropathological Italian Experience on 33 Adult Autopsies
title_full COVID-19 and the Brain: The Neuropathological Italian Experience on 33 Adult Autopsies
title_fullStr COVID-19 and the Brain: The Neuropathological Italian Experience on 33 Adult Autopsies
title_full_unstemmed COVID-19 and the Brain: The Neuropathological Italian Experience on 33 Adult Autopsies
title_short COVID-19 and the Brain: The Neuropathological Italian Experience on 33 Adult Autopsies
title_sort covid-19 and the brain: the neuropathological italian experience on 33 adult autopsies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138268/
https://www.ncbi.nlm.nih.gov/pubmed/35625558
http://dx.doi.org/10.3390/biom12050629
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