Cargando…

Physical Activity and Sedentary Time in Pregnancy: An Exploratory Study on Oxidative Stress Markers in the Placenta of Women with Obesity

Regular moderate-to-vigorous physical activity (MVPA) and reduced sedentary time (ST) improve maternal glucose metabolism in pregnancy. More MVPA and less ST outside pregnancy increase antioxidant capacity, hence, are beneficial in preventing oxidative stress. The placenta is the first line of defen...

Descripción completa

Detalles Bibliográficos
Autores principales: Zafaranieh, Saghi, Dieberger, Anna M., Leopold-Posch, Barbara, Huppertz, Berthold, Granitzer, Sebastian, Hengstschläger, Markus, Gundacker, Claudia, Desoye, Gernot, van Poppel, Mireille N. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138298/
https://www.ncbi.nlm.nih.gov/pubmed/35625806
http://dx.doi.org/10.3390/biomedicines10051069
_version_ 1784714590216519680
author Zafaranieh, Saghi
Dieberger, Anna M.
Leopold-Posch, Barbara
Huppertz, Berthold
Granitzer, Sebastian
Hengstschläger, Markus
Gundacker, Claudia
Desoye, Gernot
van Poppel, Mireille N. M.
author_facet Zafaranieh, Saghi
Dieberger, Anna M.
Leopold-Posch, Barbara
Huppertz, Berthold
Granitzer, Sebastian
Hengstschläger, Markus
Gundacker, Claudia
Desoye, Gernot
van Poppel, Mireille N. M.
author_sort Zafaranieh, Saghi
collection PubMed
description Regular moderate-to-vigorous physical activity (MVPA) and reduced sedentary time (ST) improve maternal glucose metabolism in pregnancy. More MVPA and less ST outside pregnancy increase antioxidant capacity, hence, are beneficial in preventing oxidative stress. The placenta is the first line of defense for the fetus from an adverse maternal environment, including oxidative stress. However, effects of MVPA and ST on oxidative stress markers in the placenta are unknown. The purpose of this study was to assess the association of MVPA and ST in pregnancy with oxidative stress markers in placentas of overweight/obese women (BMI ≥ 29 kg/m(2)). MVPA and ST were objectively measured with accelerometers at <20 weeks, 24–27 and 35–37 weeks of gestation. Using linear Bayesian multilevel models, the associations of MVPA and ST (mean and changes) with mRNA expression of a panel of 11 oxidative stress related markers were assessed in 96 women. MVPA was negatively correlated with HSP70 mRNA expression in a sex-independent manner and with GCLM expression only in placentas of female fetuses. ST was positively associated with HO-1 mRNA expression in placentas of male neonates. None of the other markers were associated with MVPA or ST. We speculate that increasing MVPA and reducing ST attenuates the oxidative stress state in placentas of obese pregnant women.
format Online
Article
Text
id pubmed-9138298
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91382982022-05-28 Physical Activity and Sedentary Time in Pregnancy: An Exploratory Study on Oxidative Stress Markers in the Placenta of Women with Obesity Zafaranieh, Saghi Dieberger, Anna M. Leopold-Posch, Barbara Huppertz, Berthold Granitzer, Sebastian Hengstschläger, Markus Gundacker, Claudia Desoye, Gernot van Poppel, Mireille N. M. Biomedicines Article Regular moderate-to-vigorous physical activity (MVPA) and reduced sedentary time (ST) improve maternal glucose metabolism in pregnancy. More MVPA and less ST outside pregnancy increase antioxidant capacity, hence, are beneficial in preventing oxidative stress. The placenta is the first line of defense for the fetus from an adverse maternal environment, including oxidative stress. However, effects of MVPA and ST on oxidative stress markers in the placenta are unknown. The purpose of this study was to assess the association of MVPA and ST in pregnancy with oxidative stress markers in placentas of overweight/obese women (BMI ≥ 29 kg/m(2)). MVPA and ST were objectively measured with accelerometers at <20 weeks, 24–27 and 35–37 weeks of gestation. Using linear Bayesian multilevel models, the associations of MVPA and ST (mean and changes) with mRNA expression of a panel of 11 oxidative stress related markers were assessed in 96 women. MVPA was negatively correlated with HSP70 mRNA expression in a sex-independent manner and with GCLM expression only in placentas of female fetuses. ST was positively associated with HO-1 mRNA expression in placentas of male neonates. None of the other markers were associated with MVPA or ST. We speculate that increasing MVPA and reducing ST attenuates the oxidative stress state in placentas of obese pregnant women. MDPI 2022-05-05 /pmc/articles/PMC9138298/ /pubmed/35625806 http://dx.doi.org/10.3390/biomedicines10051069 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zafaranieh, Saghi
Dieberger, Anna M.
Leopold-Posch, Barbara
Huppertz, Berthold
Granitzer, Sebastian
Hengstschläger, Markus
Gundacker, Claudia
Desoye, Gernot
van Poppel, Mireille N. M.
Physical Activity and Sedentary Time in Pregnancy: An Exploratory Study on Oxidative Stress Markers in the Placenta of Women with Obesity
title Physical Activity and Sedentary Time in Pregnancy: An Exploratory Study on Oxidative Stress Markers in the Placenta of Women with Obesity
title_full Physical Activity and Sedentary Time in Pregnancy: An Exploratory Study on Oxidative Stress Markers in the Placenta of Women with Obesity
title_fullStr Physical Activity and Sedentary Time in Pregnancy: An Exploratory Study on Oxidative Stress Markers in the Placenta of Women with Obesity
title_full_unstemmed Physical Activity and Sedentary Time in Pregnancy: An Exploratory Study on Oxidative Stress Markers in the Placenta of Women with Obesity
title_short Physical Activity and Sedentary Time in Pregnancy: An Exploratory Study on Oxidative Stress Markers in the Placenta of Women with Obesity
title_sort physical activity and sedentary time in pregnancy: an exploratory study on oxidative stress markers in the placenta of women with obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138298/
https://www.ncbi.nlm.nih.gov/pubmed/35625806
http://dx.doi.org/10.3390/biomedicines10051069
work_keys_str_mv AT zafaraniehsaghi physicalactivityandsedentarytimeinpregnancyanexploratorystudyonoxidativestressmarkersintheplacentaofwomenwithobesity
AT diebergerannam physicalactivityandsedentarytimeinpregnancyanexploratorystudyonoxidativestressmarkersintheplacentaofwomenwithobesity
AT leopoldposchbarbara physicalactivityandsedentarytimeinpregnancyanexploratorystudyonoxidativestressmarkersintheplacentaofwomenwithobesity
AT huppertzberthold physicalactivityandsedentarytimeinpregnancyanexploratorystudyonoxidativestressmarkersintheplacentaofwomenwithobesity
AT granitzersebastian physicalactivityandsedentarytimeinpregnancyanexploratorystudyonoxidativestressmarkersintheplacentaofwomenwithobesity
AT hengstschlagermarkus physicalactivityandsedentarytimeinpregnancyanexploratorystudyonoxidativestressmarkersintheplacentaofwomenwithobesity
AT gundackerclaudia physicalactivityandsedentarytimeinpregnancyanexploratorystudyonoxidativestressmarkersintheplacentaofwomenwithobesity
AT desoyegernot physicalactivityandsedentarytimeinpregnancyanexploratorystudyonoxidativestressmarkersintheplacentaofwomenwithobesity
AT vanpoppelmireillenm physicalactivityandsedentarytimeinpregnancyanexploratorystudyonoxidativestressmarkersintheplacentaofwomenwithobesity
AT physicalactivityandsedentarytimeinpregnancyanexploratorystudyonoxidativestressmarkersintheplacentaofwomenwithobesity