Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy

The tumor microenvironment (TME) plays a key role in promoting and sustaining cancer growth. Adipose tissue (AT), due to its anatomical distribution, is a prevalent component of TME, and contributes to cancer development and progression. Cancer-associated adipocytes (CAAs), reprogrammed by cancer st...

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Autores principales: Lo Iacono, Melania, Modica, Chiara, Porcelli, Gaetana, Brancato, Ornella Roberta, Muratore, Giampaolo, Bianca, Paola, Gaggianesi, Miriam, Turdo, Alice, Veschi, Veronica, Todaro, Matilde, Di Franco, Simone, Stassi, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138344/
https://www.ncbi.nlm.nih.gov/pubmed/35625629
http://dx.doi.org/10.3390/biom12050702
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author Lo Iacono, Melania
Modica, Chiara
Porcelli, Gaetana
Brancato, Ornella Roberta
Muratore, Giampaolo
Bianca, Paola
Gaggianesi, Miriam
Turdo, Alice
Veschi, Veronica
Todaro, Matilde
Di Franco, Simone
Stassi, Giorgio
author_facet Lo Iacono, Melania
Modica, Chiara
Porcelli, Gaetana
Brancato, Ornella Roberta
Muratore, Giampaolo
Bianca, Paola
Gaggianesi, Miriam
Turdo, Alice
Veschi, Veronica
Todaro, Matilde
Di Franco, Simone
Stassi, Giorgio
author_sort Lo Iacono, Melania
collection PubMed
description The tumor microenvironment (TME) plays a key role in promoting and sustaining cancer growth. Adipose tissue (AT), due to its anatomical distribution, is a prevalent component of TME, and contributes to cancer development and progression. Cancer-associated adipocytes (CAAs), reprogrammed by cancer stem cells (CSCs), drive cancer progression by releasing metabolites and inflammatory adipokines. In this review, we highlight the mechanisms underlying the bidirectional crosstalk among CAAs, CSCs, and stromal cells. Moreover, we focus on the recent advances in the therapeutic targeting of adipocyte-released factors as an innovative strategy to counteract cancer progression.
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spelling pubmed-91383442022-05-28 Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy Lo Iacono, Melania Modica, Chiara Porcelli, Gaetana Brancato, Ornella Roberta Muratore, Giampaolo Bianca, Paola Gaggianesi, Miriam Turdo, Alice Veschi, Veronica Todaro, Matilde Di Franco, Simone Stassi, Giorgio Biomolecules Review The tumor microenvironment (TME) plays a key role in promoting and sustaining cancer growth. Adipose tissue (AT), due to its anatomical distribution, is a prevalent component of TME, and contributes to cancer development and progression. Cancer-associated adipocytes (CAAs), reprogrammed by cancer stem cells (CSCs), drive cancer progression by releasing metabolites and inflammatory adipokines. In this review, we highlight the mechanisms underlying the bidirectional crosstalk among CAAs, CSCs, and stromal cells. Moreover, we focus on the recent advances in the therapeutic targeting of adipocyte-released factors as an innovative strategy to counteract cancer progression. MDPI 2022-05-14 /pmc/articles/PMC9138344/ /pubmed/35625629 http://dx.doi.org/10.3390/biom12050702 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lo Iacono, Melania
Modica, Chiara
Porcelli, Gaetana
Brancato, Ornella Roberta
Muratore, Giampaolo
Bianca, Paola
Gaggianesi, Miriam
Turdo, Alice
Veschi, Veronica
Todaro, Matilde
Di Franco, Simone
Stassi, Giorgio
Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy
title Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy
title_full Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy
title_fullStr Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy
title_full_unstemmed Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy
title_short Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy
title_sort targeting of the peritumoral adipose tissue microenvironment as an innovative antitumor therapeutic strategy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138344/
https://www.ncbi.nlm.nih.gov/pubmed/35625629
http://dx.doi.org/10.3390/biom12050702
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