TP53 Pathogenic Variants in Early-Onset Breast Cancer Patients Fulfilling Hereditary Breast and Ovary Cancer and Li-Fraumeni-like Syndromes

TP53 gene mutation is the most common genetic alteration in human malignant tumors and is mainly responsible for Li-Fraumeni syndrome. Among the several cancers related to this syndrome, breast cancer (BC) is the most common. The TP53 p.R337H germline pathogenic variant is highly prevalent in Brazil...

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Detalles Bibliográficos
Autores principales: da Silva, Paula Francinete Faustino, Goveia, Rebeca Mota, Teixeira, Thaís Bomfim, Gamba, Bruno Faulin, de Lima, Aliny Pereira, Rogatto, Sílvia Regina, Silveira-Lacerda, Elisângela de Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138348/
https://www.ncbi.nlm.nih.gov/pubmed/35625568
http://dx.doi.org/10.3390/biom12050640

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