ADP-Induced Conformational Transition of Human Adenylate Kinase 1 Is Triggered by Suppressing Internal Motion of α(3)α(4) and α(7)α(8) Fragments on the ps-ns Timescale

Human adenylate kinase 1 (hAK1) plays a vital role in the energetic and metabolic regulation of cell life, and impaired functions of hAK1 are closely associated with many diseases. In the presence of Mg(2+) ions, hAK1 in vivo can catalyze two ADP molecules into one ATP and one AMP molecule, activati...

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Detalles Bibliográficos
Autores principales: Guo, Chenyun, Zhang, Haoran, Lin, Weiliang, Chen, Hanyu, Chang, Ting, Wu, Zhihua, Yu, Jiaxin, Lin, Donghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138365/
https://www.ncbi.nlm.nih.gov/pubmed/35625598
http://dx.doi.org/10.3390/biom12050671

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