Breast Cancer Therapy: The Potential Role of Mesenchymal Stem Cells in Translational Biomedical Research

The potential role of mesenchymal stem cells (MSCs) in the treatment of metastatic cancers, including breast cancer, has been investigated for many years leading to encouraging results. The role of fat grafting and the related adipose-derived mesenchymal stem cells (AD-MSCs) has been detailed and de...

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Detalles Bibliográficos
Autor principal: Gentile, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138371/
https://www.ncbi.nlm.nih.gov/pubmed/35625915
http://dx.doi.org/10.3390/biomedicines10051179
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author Gentile, Pietro
author_facet Gentile, Pietro
author_sort Gentile, Pietro
collection PubMed
description The potential role of mesenchymal stem cells (MSCs) in the treatment of metastatic cancers, including breast cancer, has been investigated for many years leading to encouraging results. The role of fat grafting and the related adipose-derived mesenchymal stem cells (AD-MSCs) has been detailed and described for breast reconstruction purposes confirming the safety of AD-MSCs. MSCs have great potential for delivering anticancer agents, suicide genes, and oncolytic viruses to tumors. Currently, many studies have focused on the products of MSCs, including extracellular vesicles (EVs), as a cell-free therapy. This work aimed to review and discuss the current knowledge on MSCs and their EVs in breast cancer therapy.
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spelling pubmed-91383712022-05-28 Breast Cancer Therapy: The Potential Role of Mesenchymal Stem Cells in Translational Biomedical Research Gentile, Pietro Biomedicines Review The potential role of mesenchymal stem cells (MSCs) in the treatment of metastatic cancers, including breast cancer, has been investigated for many years leading to encouraging results. The role of fat grafting and the related adipose-derived mesenchymal stem cells (AD-MSCs) has been detailed and described for breast reconstruction purposes confirming the safety of AD-MSCs. MSCs have great potential for delivering anticancer agents, suicide genes, and oncolytic viruses to tumors. Currently, many studies have focused on the products of MSCs, including extracellular vesicles (EVs), as a cell-free therapy. This work aimed to review and discuss the current knowledge on MSCs and their EVs in breast cancer therapy. MDPI 2022-05-19 /pmc/articles/PMC9138371/ /pubmed/35625915 http://dx.doi.org/10.3390/biomedicines10051179 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gentile, Pietro
Breast Cancer Therapy: The Potential Role of Mesenchymal Stem Cells in Translational Biomedical Research
title Breast Cancer Therapy: The Potential Role of Mesenchymal Stem Cells in Translational Biomedical Research
title_full Breast Cancer Therapy: The Potential Role of Mesenchymal Stem Cells in Translational Biomedical Research
title_fullStr Breast Cancer Therapy: The Potential Role of Mesenchymal Stem Cells in Translational Biomedical Research
title_full_unstemmed Breast Cancer Therapy: The Potential Role of Mesenchymal Stem Cells in Translational Biomedical Research
title_short Breast Cancer Therapy: The Potential Role of Mesenchymal Stem Cells in Translational Biomedical Research
title_sort breast cancer therapy: the potential role of mesenchymal stem cells in translational biomedical research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138371/
https://www.ncbi.nlm.nih.gov/pubmed/35625915
http://dx.doi.org/10.3390/biomedicines10051179
work_keys_str_mv AT gentilepietro breastcancertherapythepotentialroleofmesenchymalstemcellsintranslationalbiomedicalresearch

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