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Effect of Vitamin D on Graft-versus-Host Disease

The different cell subsets of the immune system express the vitamin D receptor (VDR). Through the VDR, vitamin D exerts different functions that influence immune responses, as previously shown in different preclinical models. Based on this background, retrospective studies explored the impacts of vi...

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Autores principales: Rodríguez-Gil, Alfonso, Carrillo-Cruz, Estrella, Marrero-Cepeda, Cristina, Rodríguez, Guillermo, Pérez-Simón, José A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138416/
https://www.ncbi.nlm.nih.gov/pubmed/35625724
http://dx.doi.org/10.3390/biomedicines10050987
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author Rodríguez-Gil, Alfonso
Carrillo-Cruz, Estrella
Marrero-Cepeda, Cristina
Rodríguez, Guillermo
Pérez-Simón, José A.
author_facet Rodríguez-Gil, Alfonso
Carrillo-Cruz, Estrella
Marrero-Cepeda, Cristina
Rodríguez, Guillermo
Pérez-Simón, José A.
author_sort Rodríguez-Gil, Alfonso
collection PubMed
description The different cell subsets of the immune system express the vitamin D receptor (VDR). Through the VDR, vitamin D exerts different functions that influence immune responses, as previously shown in different preclinical models. Based on this background, retrospective studies explored the impacts of vitamin D levels on the outcomes of patients undergoing allogeneic hematopoietic stem-cell transplantation, showing that vitamin D deficiency is related to an increased risk of complications, especially graft-versus-host disease. These results were confirmed in a prospective cohort trial, although further studies are required to confirm this data. In addition, the role of vitamin D on the treatment of hematologic malignancies was also explored. Considering this dual effect on both the immune systems and tumor cells of patients with hematologic malignancies, vitamin D might be useful in this setting to decrease both graft-versus-host disease and relapse rates.
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spelling pubmed-91384162022-05-28 Effect of Vitamin D on Graft-versus-Host Disease Rodríguez-Gil, Alfonso Carrillo-Cruz, Estrella Marrero-Cepeda, Cristina Rodríguez, Guillermo Pérez-Simón, José A. Biomedicines Review The different cell subsets of the immune system express the vitamin D receptor (VDR). Through the VDR, vitamin D exerts different functions that influence immune responses, as previously shown in different preclinical models. Based on this background, retrospective studies explored the impacts of vitamin D levels on the outcomes of patients undergoing allogeneic hematopoietic stem-cell transplantation, showing that vitamin D deficiency is related to an increased risk of complications, especially graft-versus-host disease. These results were confirmed in a prospective cohort trial, although further studies are required to confirm this data. In addition, the role of vitamin D on the treatment of hematologic malignancies was also explored. Considering this dual effect on both the immune systems and tumor cells of patients with hematologic malignancies, vitamin D might be useful in this setting to decrease both graft-versus-host disease and relapse rates. MDPI 2022-04-24 /pmc/articles/PMC9138416/ /pubmed/35625724 http://dx.doi.org/10.3390/biomedicines10050987 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rodríguez-Gil, Alfonso
Carrillo-Cruz, Estrella
Marrero-Cepeda, Cristina
Rodríguez, Guillermo
Pérez-Simón, José A.
Effect of Vitamin D on Graft-versus-Host Disease
title Effect of Vitamin D on Graft-versus-Host Disease
title_full Effect of Vitamin D on Graft-versus-Host Disease
title_fullStr Effect of Vitamin D on Graft-versus-Host Disease
title_full_unstemmed Effect of Vitamin D on Graft-versus-Host Disease
title_short Effect of Vitamin D on Graft-versus-Host Disease
title_sort effect of vitamin d on graft-versus-host disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138416/
https://www.ncbi.nlm.nih.gov/pubmed/35625724
http://dx.doi.org/10.3390/biomedicines10050987
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