Cargando…
Accumulation of Arachidonic Acid, Precursor of Pro-Inflammatory Eicosanoids, in Adipose Tissue of Obese Women: Association with Breast Cancer Aggressiveness Indicators
While obesity is linked to cancer risk, no studies have explored the consequences of body mass index (BMI) on fatty acid profiles in breast adipose tissue and on breast tumor aggressiveness indicators. Because of this, 261 breast adipose tissue samples of women with invasive breast carcinoma were an...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138452/ https://www.ncbi.nlm.nih.gov/pubmed/35625732 http://dx.doi.org/10.3390/biomedicines10050995 |
_version_ | 1784714626325282816 |
---|---|
author | Ouldamer, Lobna Jourdan, Marie-Lise Pinault, Michelle Arbion, Flavie Goupille, Caroline |
author_facet | Ouldamer, Lobna Jourdan, Marie-Lise Pinault, Michelle Arbion, Flavie Goupille, Caroline |
author_sort | Ouldamer, Lobna |
collection | PubMed |
description | While obesity is linked to cancer risk, no studies have explored the consequences of body mass index (BMI) on fatty acid profiles in breast adipose tissue and on breast tumor aggressiveness indicators. Because of this, 261 breast adipose tissue samples of women with invasive breast carcinoma were analyzed. Fatty acid profile was established by gas chromatography. For normal-weight women, major changes in fatty acid profile occurs after menopause, with the enrichment of long-chain polyunsaturated fatty acids (LC-PUFAs) of both n-6 and n-3 series enrichment, but a stable LC-PUFAs n-6/n-3 ratio across age. BMI impact was analyzed by age subgroups to overcome the age effect. BMI increase is associated with LC-PUFAs n-6 accumulation, including arachidonic acid. Positive correlations between BMI and several LC-PUFAs n-6 were observed, as well as a strong imbalance in the LC-PUFAs n-6/n-3 ratio. Regarding cancer, axillary lymph nodes (p = 0.02) and inflammatory breast cancer (p = 0.08) are more frequently involved in obese women. Increased BMI induces an LC-PUFAs n-6 accumulation, including arachidonic acid, in adipose tissue. This may participate in the development of low-grade inflammation in obese women and breast tumor progression. These results suggest the value of lifestyle and LC-PUFAs n-3 potential, in the context of obesity and breast cancer secondary/tertiary prevention. |
format | Online Article Text |
id | pubmed-9138452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91384522022-05-28 Accumulation of Arachidonic Acid, Precursor of Pro-Inflammatory Eicosanoids, in Adipose Tissue of Obese Women: Association with Breast Cancer Aggressiveness Indicators Ouldamer, Lobna Jourdan, Marie-Lise Pinault, Michelle Arbion, Flavie Goupille, Caroline Biomedicines Article While obesity is linked to cancer risk, no studies have explored the consequences of body mass index (BMI) on fatty acid profiles in breast adipose tissue and on breast tumor aggressiveness indicators. Because of this, 261 breast adipose tissue samples of women with invasive breast carcinoma were analyzed. Fatty acid profile was established by gas chromatography. For normal-weight women, major changes in fatty acid profile occurs after menopause, with the enrichment of long-chain polyunsaturated fatty acids (LC-PUFAs) of both n-6 and n-3 series enrichment, but a stable LC-PUFAs n-6/n-3 ratio across age. BMI impact was analyzed by age subgroups to overcome the age effect. BMI increase is associated with LC-PUFAs n-6 accumulation, including arachidonic acid. Positive correlations between BMI and several LC-PUFAs n-6 were observed, as well as a strong imbalance in the LC-PUFAs n-6/n-3 ratio. Regarding cancer, axillary lymph nodes (p = 0.02) and inflammatory breast cancer (p = 0.08) are more frequently involved in obese women. Increased BMI induces an LC-PUFAs n-6 accumulation, including arachidonic acid, in adipose tissue. This may participate in the development of low-grade inflammation in obese women and breast tumor progression. These results suggest the value of lifestyle and LC-PUFAs n-3 potential, in the context of obesity and breast cancer secondary/tertiary prevention. MDPI 2022-04-26 /pmc/articles/PMC9138452/ /pubmed/35625732 http://dx.doi.org/10.3390/biomedicines10050995 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ouldamer, Lobna Jourdan, Marie-Lise Pinault, Michelle Arbion, Flavie Goupille, Caroline Accumulation of Arachidonic Acid, Precursor of Pro-Inflammatory Eicosanoids, in Adipose Tissue of Obese Women: Association with Breast Cancer Aggressiveness Indicators |
title | Accumulation of Arachidonic Acid, Precursor of Pro-Inflammatory Eicosanoids, in Adipose Tissue of Obese Women: Association with Breast Cancer Aggressiveness Indicators |
title_full | Accumulation of Arachidonic Acid, Precursor of Pro-Inflammatory Eicosanoids, in Adipose Tissue of Obese Women: Association with Breast Cancer Aggressiveness Indicators |
title_fullStr | Accumulation of Arachidonic Acid, Precursor of Pro-Inflammatory Eicosanoids, in Adipose Tissue of Obese Women: Association with Breast Cancer Aggressiveness Indicators |
title_full_unstemmed | Accumulation of Arachidonic Acid, Precursor of Pro-Inflammatory Eicosanoids, in Adipose Tissue of Obese Women: Association with Breast Cancer Aggressiveness Indicators |
title_short | Accumulation of Arachidonic Acid, Precursor of Pro-Inflammatory Eicosanoids, in Adipose Tissue of Obese Women: Association with Breast Cancer Aggressiveness Indicators |
title_sort | accumulation of arachidonic acid, precursor of pro-inflammatory eicosanoids, in adipose tissue of obese women: association with breast cancer aggressiveness indicators |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138452/ https://www.ncbi.nlm.nih.gov/pubmed/35625732 http://dx.doi.org/10.3390/biomedicines10050995 |
work_keys_str_mv | AT ouldamerlobna accumulationofarachidonicacidprecursorofproinflammatoryeicosanoidsinadiposetissueofobesewomenassociationwithbreastcanceraggressivenessindicators AT jourdanmarielise accumulationofarachidonicacidprecursorofproinflammatoryeicosanoidsinadiposetissueofobesewomenassociationwithbreastcanceraggressivenessindicators AT pinaultmichelle accumulationofarachidonicacidprecursorofproinflammatoryeicosanoidsinadiposetissueofobesewomenassociationwithbreastcanceraggressivenessindicators AT arbionflavie accumulationofarachidonicacidprecursorofproinflammatoryeicosanoidsinadiposetissueofobesewomenassociationwithbreastcanceraggressivenessindicators AT goupillecaroline accumulationofarachidonicacidprecursorofproinflammatoryeicosanoidsinadiposetissueofobesewomenassociationwithbreastcanceraggressivenessindicators |