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Predictors of Acute Kidney Disease Severity in Hospitalized Patients with Acute Kidney Injury

Acute kidney disease (AKD) forms part of the continuum of acute kidney injury (AKI) and worsens clinical outcomes. Currently, the predictors of AKD severity have yet to be established. We conducted a retrospective investigation involving 310 hospitalized patients with AKI and stratified them based o...

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Autores principales: Hsu, Pai-Chin, Liu, Chih-Han, Lee, Wen-Chin, Wu, Chien-Hsing, Lee, Chien-Te, Su, Chien-Hao, Wang, Yu-Chin Lily, Tsai, Kai-Fan, Chiou, Terry Ting-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138458/
https://www.ncbi.nlm.nih.gov/pubmed/35625818
http://dx.doi.org/10.3390/biomedicines10051081
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author Hsu, Pai-Chin
Liu, Chih-Han
Lee, Wen-Chin
Wu, Chien-Hsing
Lee, Chien-Te
Su, Chien-Hao
Wang, Yu-Chin Lily
Tsai, Kai-Fan
Chiou, Terry Ting-Yu
author_facet Hsu, Pai-Chin
Liu, Chih-Han
Lee, Wen-Chin
Wu, Chien-Hsing
Lee, Chien-Te
Su, Chien-Hao
Wang, Yu-Chin Lily
Tsai, Kai-Fan
Chiou, Terry Ting-Yu
author_sort Hsu, Pai-Chin
collection PubMed
description Acute kidney disease (AKD) forms part of the continuum of acute kidney injury (AKI) and worsens clinical outcomes. Currently, the predictors of AKD severity have yet to be established. We conducted a retrospective investigation involving 310 hospitalized patients with AKI and stratified them based on the AKD stages defined by the Acute Dialysis Quality Initiative criteria. Demographic, clinical, hematologic, and biochemical profiles, as well as 30-day outcomes, were compared between subgroups. In the analysis, the use of offending drugs (odds ratio, OR (95% confidence interval, CI), AKD stage 3 vs. non-AKD, 3.132 (1.304–7.526), p = 0.011, AKD stage 2 vs. non-AKD, 2.314 (1.049–5.107), p = 0.038), high AKI severity (OR (95% CI), AKD stage 3 vs. non-AKD, 6.214 (2.658–14.526), p < 0.001), and early dialysis requirement (OR (95% CI), AKD stage 3 vs. non-AKD, 3.366 (1.008–11.242), p = 0.049) were identified as independent predictors of AKD severity. Moreover, a higher AKD severity was associated with higher 30-day mortality and lower dialysis-independent survival rates. In conclusion, our study demonstrated that offending drug use, AKI severity, and early dialysis requirement were independent predictors of AKD severity, and high AKD severity had negative impact on post-AKI outcomes.
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spelling pubmed-91384582022-05-28 Predictors of Acute Kidney Disease Severity in Hospitalized Patients with Acute Kidney Injury Hsu, Pai-Chin Liu, Chih-Han Lee, Wen-Chin Wu, Chien-Hsing Lee, Chien-Te Su, Chien-Hao Wang, Yu-Chin Lily Tsai, Kai-Fan Chiou, Terry Ting-Yu Biomedicines Article Acute kidney disease (AKD) forms part of the continuum of acute kidney injury (AKI) and worsens clinical outcomes. Currently, the predictors of AKD severity have yet to be established. We conducted a retrospective investigation involving 310 hospitalized patients with AKI and stratified them based on the AKD stages defined by the Acute Dialysis Quality Initiative criteria. Demographic, clinical, hematologic, and biochemical profiles, as well as 30-day outcomes, were compared between subgroups. In the analysis, the use of offending drugs (odds ratio, OR (95% confidence interval, CI), AKD stage 3 vs. non-AKD, 3.132 (1.304–7.526), p = 0.011, AKD stage 2 vs. non-AKD, 2.314 (1.049–5.107), p = 0.038), high AKI severity (OR (95% CI), AKD stage 3 vs. non-AKD, 6.214 (2.658–14.526), p < 0.001), and early dialysis requirement (OR (95% CI), AKD stage 3 vs. non-AKD, 3.366 (1.008–11.242), p = 0.049) were identified as independent predictors of AKD severity. Moreover, a higher AKD severity was associated with higher 30-day mortality and lower dialysis-independent survival rates. In conclusion, our study demonstrated that offending drug use, AKI severity, and early dialysis requirement were independent predictors of AKD severity, and high AKD severity had negative impact on post-AKI outcomes. MDPI 2022-05-06 /pmc/articles/PMC9138458/ /pubmed/35625818 http://dx.doi.org/10.3390/biomedicines10051081 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hsu, Pai-Chin
Liu, Chih-Han
Lee, Wen-Chin
Wu, Chien-Hsing
Lee, Chien-Te
Su, Chien-Hao
Wang, Yu-Chin Lily
Tsai, Kai-Fan
Chiou, Terry Ting-Yu
Predictors of Acute Kidney Disease Severity in Hospitalized Patients with Acute Kidney Injury
title Predictors of Acute Kidney Disease Severity in Hospitalized Patients with Acute Kidney Injury
title_full Predictors of Acute Kidney Disease Severity in Hospitalized Patients with Acute Kidney Injury
title_fullStr Predictors of Acute Kidney Disease Severity in Hospitalized Patients with Acute Kidney Injury
title_full_unstemmed Predictors of Acute Kidney Disease Severity in Hospitalized Patients with Acute Kidney Injury
title_short Predictors of Acute Kidney Disease Severity in Hospitalized Patients with Acute Kidney Injury
title_sort predictors of acute kidney disease severity in hospitalized patients with acute kidney injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138458/
https://www.ncbi.nlm.nih.gov/pubmed/35625818
http://dx.doi.org/10.3390/biomedicines10051081
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