Amyloid Beta Oligomers-Induced Ca(2+) Entry Pathways: Role of Neuronal Networks, NMDA Receptors and Amyloid Channel Formation

The molecular basis of amyloid toxicity in Alzheimer’s disease (AD) remains controversial. Amyloid β (Aβ) oligomers promote Ca(2+) influx, mitochondrial Ca(2+) overload and apoptosis in hippocampal neurons in vivo and in vitro, but the primary Ca(2+) entry pathways are unclear. We studied Ca(2+) ent...

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Detalles Bibliográficos
Autores principales: Caballero, Erica, Hernando-Pérez, Elena, Tapias, Victor, Calvo-Rodríguez, María, Villalobos, Carlos, Núñez, Lucía
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138537/
https://www.ncbi.nlm.nih.gov/pubmed/35625890
http://dx.doi.org/10.3390/biomedicines10051153

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