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Assessment of Nanoparticle-Mediated Tumor Oxygen Modulation by Photoacoustic Imaging

Photoacoustic imaging (PAI) is an invaluable tool in biomedical imaging, as it provides anatomical and functional information in real time. Its ability to image at clinically relevant depths with high spatial resolution using endogenous tissues as contrast agents constitutes its major advantage. One...

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Autores principales: Sivasubramanian, Maharajan, Lo, Leu-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138624/
https://www.ncbi.nlm.nih.gov/pubmed/35624636
http://dx.doi.org/10.3390/bios12050336
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author Sivasubramanian, Maharajan
Lo, Leu-Wei
author_facet Sivasubramanian, Maharajan
Lo, Leu-Wei
author_sort Sivasubramanian, Maharajan
collection PubMed
description Photoacoustic imaging (PAI) is an invaluable tool in biomedical imaging, as it provides anatomical and functional information in real time. Its ability to image at clinically relevant depths with high spatial resolution using endogenous tissues as contrast agents constitutes its major advantage. One of the most important applications of PAI is to quantify tissue oxygen saturation by measuring the differential absorption characteristics of oxy and deoxy Hb. Consequently, PAI can be utilized to monitor tumor-related hypoxia, which is a crucial factor in tumor microenvironments that has a strong influence on tumor invasiveness. Reactive oxygen species (ROS)-based therapies, such as photodynamic therapy, radiotherapy, and sonodynamic therapy, are oxygen-consuming, and tumor hypoxia is detrimental to their efficacy. Therefore, a persistent demand exists for agents that can supply oxygen to tumors for better ROS-based therapeutic outcomes. Among the various strategies, NP-mediated supplemental tumor oxygenation is especially encouraging due to its physio-chemical, tumor targeting, and theranostic properties. Here, we focus on NP-based tumor oxygenation, which includes NP as oxygen carriers and oxygen-generating strategies to alleviate hypoxia monitored by PAI. The information obtained from quantitative tumor oxygenation by PAI not only supports optimal therapeutic design but also serves as a highly effective tool to predict therapeutic outcomes.
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spelling pubmed-91386242022-05-28 Assessment of Nanoparticle-Mediated Tumor Oxygen Modulation by Photoacoustic Imaging Sivasubramanian, Maharajan Lo, Leu-Wei Biosensors (Basel) Review Photoacoustic imaging (PAI) is an invaluable tool in biomedical imaging, as it provides anatomical and functional information in real time. Its ability to image at clinically relevant depths with high spatial resolution using endogenous tissues as contrast agents constitutes its major advantage. One of the most important applications of PAI is to quantify tissue oxygen saturation by measuring the differential absorption characteristics of oxy and deoxy Hb. Consequently, PAI can be utilized to monitor tumor-related hypoxia, which is a crucial factor in tumor microenvironments that has a strong influence on tumor invasiveness. Reactive oxygen species (ROS)-based therapies, such as photodynamic therapy, radiotherapy, and sonodynamic therapy, are oxygen-consuming, and tumor hypoxia is detrimental to their efficacy. Therefore, a persistent demand exists for agents that can supply oxygen to tumors for better ROS-based therapeutic outcomes. Among the various strategies, NP-mediated supplemental tumor oxygenation is especially encouraging due to its physio-chemical, tumor targeting, and theranostic properties. Here, we focus on NP-based tumor oxygenation, which includes NP as oxygen carriers and oxygen-generating strategies to alleviate hypoxia monitored by PAI. The information obtained from quantitative tumor oxygenation by PAI not only supports optimal therapeutic design but also serves as a highly effective tool to predict therapeutic outcomes. MDPI 2022-05-13 /pmc/articles/PMC9138624/ /pubmed/35624636 http://dx.doi.org/10.3390/bios12050336 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sivasubramanian, Maharajan
Lo, Leu-Wei
Assessment of Nanoparticle-Mediated Tumor Oxygen Modulation by Photoacoustic Imaging
title Assessment of Nanoparticle-Mediated Tumor Oxygen Modulation by Photoacoustic Imaging
title_full Assessment of Nanoparticle-Mediated Tumor Oxygen Modulation by Photoacoustic Imaging
title_fullStr Assessment of Nanoparticle-Mediated Tumor Oxygen Modulation by Photoacoustic Imaging
title_full_unstemmed Assessment of Nanoparticle-Mediated Tumor Oxygen Modulation by Photoacoustic Imaging
title_short Assessment of Nanoparticle-Mediated Tumor Oxygen Modulation by Photoacoustic Imaging
title_sort assessment of nanoparticle-mediated tumor oxygen modulation by photoacoustic imaging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138624/
https://www.ncbi.nlm.nih.gov/pubmed/35624636
http://dx.doi.org/10.3390/bios12050336
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