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Brain-Derived Neurotropic Factor in Neurodegenerative Disorders

Globally, neurodegenerative diseases cause a significant degree of disability and distress. Brain-derived neurotrophic factor (BDNF), primarily found in the brain, has a substantial role in the development and maintenance of various nerve roles and is associated with the family of neurotrophins, inc...

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Autores principales: Ibrahim, Abdallah Mohammad, Chauhan, Lalita, Bhardwaj, Aditi, Sharma, Anjali, Fayaz, Faizana, Kumar, Bhumika, Alhashmi, Mohamed, AlHajri, Noora, Alam, Md Sabir, Pottoo, Faheem Hyder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138678/
https://www.ncbi.nlm.nih.gov/pubmed/35625880
http://dx.doi.org/10.3390/biomedicines10051143
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author Ibrahim, Abdallah Mohammad
Chauhan, Lalita
Bhardwaj, Aditi
Sharma, Anjali
Fayaz, Faizana
Kumar, Bhumika
Alhashmi, Mohamed
AlHajri, Noora
Alam, Md Sabir
Pottoo, Faheem Hyder
author_facet Ibrahim, Abdallah Mohammad
Chauhan, Lalita
Bhardwaj, Aditi
Sharma, Anjali
Fayaz, Faizana
Kumar, Bhumika
Alhashmi, Mohamed
AlHajri, Noora
Alam, Md Sabir
Pottoo, Faheem Hyder
author_sort Ibrahim, Abdallah Mohammad
collection PubMed
description Globally, neurodegenerative diseases cause a significant degree of disability and distress. Brain-derived neurotrophic factor (BDNF), primarily found in the brain, has a substantial role in the development and maintenance of various nerve roles and is associated with the family of neurotrophins, including neuronal growth factor (NGF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5). BDNF has affinity with tropomyosin receptor kinase B (TrKB), which is found in the brain in large amounts and is expressed in several cells. Several studies have shown that decrease in BDNF causes an imbalance in neuronal functioning and survival. Moreover, BDNF has several important roles, such as improving synaptic plasticity and contributing to long-lasting memory formation. BDNF has been linked to the pathology of the most common neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease. This review aims to describe recent efforts to understand the connection between the level of BDNF and neurodegenerative diseases. Several studies have shown that a high level of BDNF is associated with a lower risk for developing a neurodegenerative disease.
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spelling pubmed-91386782022-05-28 Brain-Derived Neurotropic Factor in Neurodegenerative Disorders Ibrahim, Abdallah Mohammad Chauhan, Lalita Bhardwaj, Aditi Sharma, Anjali Fayaz, Faizana Kumar, Bhumika Alhashmi, Mohamed AlHajri, Noora Alam, Md Sabir Pottoo, Faheem Hyder Biomedicines Review Globally, neurodegenerative diseases cause a significant degree of disability and distress. Brain-derived neurotrophic factor (BDNF), primarily found in the brain, has a substantial role in the development and maintenance of various nerve roles and is associated with the family of neurotrophins, including neuronal growth factor (NGF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5). BDNF has affinity with tropomyosin receptor kinase B (TrKB), which is found in the brain in large amounts and is expressed in several cells. Several studies have shown that decrease in BDNF causes an imbalance in neuronal functioning and survival. Moreover, BDNF has several important roles, such as improving synaptic plasticity and contributing to long-lasting memory formation. BDNF has been linked to the pathology of the most common neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease. This review aims to describe recent efforts to understand the connection between the level of BDNF and neurodegenerative diseases. Several studies have shown that a high level of BDNF is associated with a lower risk for developing a neurodegenerative disease. MDPI 2022-05-16 /pmc/articles/PMC9138678/ /pubmed/35625880 http://dx.doi.org/10.3390/biomedicines10051143 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ibrahim, Abdallah Mohammad
Chauhan, Lalita
Bhardwaj, Aditi
Sharma, Anjali
Fayaz, Faizana
Kumar, Bhumika
Alhashmi, Mohamed
AlHajri, Noora
Alam, Md Sabir
Pottoo, Faheem Hyder
Brain-Derived Neurotropic Factor in Neurodegenerative Disorders
title Brain-Derived Neurotropic Factor in Neurodegenerative Disorders
title_full Brain-Derived Neurotropic Factor in Neurodegenerative Disorders
title_fullStr Brain-Derived Neurotropic Factor in Neurodegenerative Disorders
title_full_unstemmed Brain-Derived Neurotropic Factor in Neurodegenerative Disorders
title_short Brain-Derived Neurotropic Factor in Neurodegenerative Disorders
title_sort brain-derived neurotropic factor in neurodegenerative disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138678/
https://www.ncbi.nlm.nih.gov/pubmed/35625880
http://dx.doi.org/10.3390/biomedicines10051143
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