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Site and Mechanism of Recurrent Pontine Infarction: A Hospital-Based Follow-Up Study

Although pontine infarction is the most common subtype of posterior circulation stroke, there has been little research focusing on recurrent pontine infarction. Our study aimed to investigate the factors associated with site and mechanism of recurrent pontine infarction. Patients with acute isolated...

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Autores principales: Wu, Li, Li, Youfu, Ye, Zeming, Liu, Dezhi, Dai, Zheng, Zhu, Juehua, Chen, Hongbing, Li, Chenghao, Lie, Chaowei, Jiang, Yongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138740/
https://www.ncbi.nlm.nih.gov/pubmed/35624909
http://dx.doi.org/10.3390/brainsci12050520
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author Wu, Li
Li, Youfu
Ye, Zeming
Liu, Dezhi
Dai, Zheng
Zhu, Juehua
Chen, Hongbing
Li, Chenghao
Lie, Chaowei
Jiang, Yongjun
author_facet Wu, Li
Li, Youfu
Ye, Zeming
Liu, Dezhi
Dai, Zheng
Zhu, Juehua
Chen, Hongbing
Li, Chenghao
Lie, Chaowei
Jiang, Yongjun
author_sort Wu, Li
collection PubMed
description Although pontine infarction is the most common subtype of posterior circulation stroke, there has been little research focusing on recurrent pontine infarction. Our study aimed to investigate the factors associated with site and mechanism of recurrent pontine infarction. Patients with acute isolated pontine infarction were enrolled and followed up for one year. Lesion topography was determined by diffusion-weighted imaging. Mechanisms were determined based on lesion topography and other vascular, cardiologic and laboratory results. A total of 562 patients with pontine infarction were included, with 67 patients experiencing recurrence during the follow-up period. Forty-one recurrences occurred at the same site as index pontine infarction (41/67, 61.2%). Results indicated that the mechanism of index pontine infarction was significantly associated with the recurrent sites (p = 0.041, OR 2.938, 95% CI 1.044–8.268), and also with the mechanisms of recurrence (p = 0.004, OR 6.056, 95% CI 1.774–20.679). Branch atheromatous disease-induced index pontine infarction was likely to recur at the same site and with the same mechanism. Moreover, if recurrence occurred at the same site, the mechanism was probably the same as that of the index stroke (p = 0.000). Our study may help physicians treat patients with pontine infarction by predicting the site and mechanism of recurrence.
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spelling pubmed-91387402022-05-28 Site and Mechanism of Recurrent Pontine Infarction: A Hospital-Based Follow-Up Study Wu, Li Li, Youfu Ye, Zeming Liu, Dezhi Dai, Zheng Zhu, Juehua Chen, Hongbing Li, Chenghao Lie, Chaowei Jiang, Yongjun Brain Sci Article Although pontine infarction is the most common subtype of posterior circulation stroke, there has been little research focusing on recurrent pontine infarction. Our study aimed to investigate the factors associated with site and mechanism of recurrent pontine infarction. Patients with acute isolated pontine infarction were enrolled and followed up for one year. Lesion topography was determined by diffusion-weighted imaging. Mechanisms were determined based on lesion topography and other vascular, cardiologic and laboratory results. A total of 562 patients with pontine infarction were included, with 67 patients experiencing recurrence during the follow-up period. Forty-one recurrences occurred at the same site as index pontine infarction (41/67, 61.2%). Results indicated that the mechanism of index pontine infarction was significantly associated with the recurrent sites (p = 0.041, OR 2.938, 95% CI 1.044–8.268), and also with the mechanisms of recurrence (p = 0.004, OR 6.056, 95% CI 1.774–20.679). Branch atheromatous disease-induced index pontine infarction was likely to recur at the same site and with the same mechanism. Moreover, if recurrence occurred at the same site, the mechanism was probably the same as that of the index stroke (p = 0.000). Our study may help physicians treat patients with pontine infarction by predicting the site and mechanism of recurrence. MDPI 2022-04-20 /pmc/articles/PMC9138740/ /pubmed/35624909 http://dx.doi.org/10.3390/brainsci12050520 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Li
Li, Youfu
Ye, Zeming
Liu, Dezhi
Dai, Zheng
Zhu, Juehua
Chen, Hongbing
Li, Chenghao
Lie, Chaowei
Jiang, Yongjun
Site and Mechanism of Recurrent Pontine Infarction: A Hospital-Based Follow-Up Study
title Site and Mechanism of Recurrent Pontine Infarction: A Hospital-Based Follow-Up Study
title_full Site and Mechanism of Recurrent Pontine Infarction: A Hospital-Based Follow-Up Study
title_fullStr Site and Mechanism of Recurrent Pontine Infarction: A Hospital-Based Follow-Up Study
title_full_unstemmed Site and Mechanism of Recurrent Pontine Infarction: A Hospital-Based Follow-Up Study
title_short Site and Mechanism of Recurrent Pontine Infarction: A Hospital-Based Follow-Up Study
title_sort site and mechanism of recurrent pontine infarction: a hospital-based follow-up study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138740/
https://www.ncbi.nlm.nih.gov/pubmed/35624909
http://dx.doi.org/10.3390/brainsci12050520
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