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Using Vertebrate Stem and Progenitor Cells for Cellular Agriculture, State-of-the-Art, Challenges, and Future Perspectives

Global food systems are under significant pressure to provide enough food, particularly protein-rich foods whose demand is on the rise in times of crisis and inflation, as presently existing due to post-COVID-19 pandemic effects and ongoing conflict in Ukraine and resulting in looming food insecurit...

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Autores principales: Knežić, Teodora, Janjušević, Ljiljana, Djisalov, Mila, Yodmuang, Supansa, Gadjanski, Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138761/
https://www.ncbi.nlm.nih.gov/pubmed/35625626
http://dx.doi.org/10.3390/biom12050699
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author Knežić, Teodora
Janjušević, Ljiljana
Djisalov, Mila
Yodmuang, Supansa
Gadjanski, Ivana
author_facet Knežić, Teodora
Janjušević, Ljiljana
Djisalov, Mila
Yodmuang, Supansa
Gadjanski, Ivana
author_sort Knežić, Teodora
collection PubMed
description Global food systems are under significant pressure to provide enough food, particularly protein-rich foods whose demand is on the rise in times of crisis and inflation, as presently existing due to post-COVID-19 pandemic effects and ongoing conflict in Ukraine and resulting in looming food insecurity, according to FAO. Cultivated meat (CM) and cultivated seafood (CS) are protein-rich alternatives for traditional meat and fish that are obtained via cellular agriculture (CA) i.e., tissue engineering for food applications. Stem and progenitor cells are the building blocks and starting point for any CA bioprocess. This review presents CA-relevant vertebrate cell types and procedures needed for their myogenic and adipogenic differentiation since muscle and fat tissue are the primary target tissues for CM/CS production. The review also describes existing challenges, such as a need for immortalized cell lines, or physical and biochemical parameters needed for enhanced meat/fat culture efficiency and ways to address them.
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spelling pubmed-91387612022-05-28 Using Vertebrate Stem and Progenitor Cells for Cellular Agriculture, State-of-the-Art, Challenges, and Future Perspectives Knežić, Teodora Janjušević, Ljiljana Djisalov, Mila Yodmuang, Supansa Gadjanski, Ivana Biomolecules Review Global food systems are under significant pressure to provide enough food, particularly protein-rich foods whose demand is on the rise in times of crisis and inflation, as presently existing due to post-COVID-19 pandemic effects and ongoing conflict in Ukraine and resulting in looming food insecurity, according to FAO. Cultivated meat (CM) and cultivated seafood (CS) are protein-rich alternatives for traditional meat and fish that are obtained via cellular agriculture (CA) i.e., tissue engineering for food applications. Stem and progenitor cells are the building blocks and starting point for any CA bioprocess. This review presents CA-relevant vertebrate cell types and procedures needed for their myogenic and adipogenic differentiation since muscle and fat tissue are the primary target tissues for CM/CS production. The review also describes existing challenges, such as a need for immortalized cell lines, or physical and biochemical parameters needed for enhanced meat/fat culture efficiency and ways to address them. MDPI 2022-05-13 /pmc/articles/PMC9138761/ /pubmed/35625626 http://dx.doi.org/10.3390/biom12050699 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Knežić, Teodora
Janjušević, Ljiljana
Djisalov, Mila
Yodmuang, Supansa
Gadjanski, Ivana
Using Vertebrate Stem and Progenitor Cells for Cellular Agriculture, State-of-the-Art, Challenges, and Future Perspectives
title Using Vertebrate Stem and Progenitor Cells for Cellular Agriculture, State-of-the-Art, Challenges, and Future Perspectives
title_full Using Vertebrate Stem and Progenitor Cells for Cellular Agriculture, State-of-the-Art, Challenges, and Future Perspectives
title_fullStr Using Vertebrate Stem and Progenitor Cells for Cellular Agriculture, State-of-the-Art, Challenges, and Future Perspectives
title_full_unstemmed Using Vertebrate Stem and Progenitor Cells for Cellular Agriculture, State-of-the-Art, Challenges, and Future Perspectives
title_short Using Vertebrate Stem and Progenitor Cells for Cellular Agriculture, State-of-the-Art, Challenges, and Future Perspectives
title_sort using vertebrate stem and progenitor cells for cellular agriculture, state-of-the-art, challenges, and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138761/
https://www.ncbi.nlm.nih.gov/pubmed/35625626
http://dx.doi.org/10.3390/biom12050699
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