Current Development of Nano-Drug Delivery to Target Macrophages

Macrophages are the most important innate immune cells that participate in various inflammation-related diseases. Therefore, macrophage-related pathological processes are essential targets in the diagnosis and treatment of diseases. Since nanoparticles (NPs) can be preferentially taken up by macroph...

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Detalles Bibliográficos
Autores principales: Cai, Donglin, Gao, Wendong, Li, Zhelun, Zhang, Yufeng, Xiao, Lan, Xiao, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139084/
https://www.ncbi.nlm.nih.gov/pubmed/35625939
http://dx.doi.org/10.3390/biomedicines10051203
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author Cai, Donglin
Gao, Wendong
Li, Zhelun
Zhang, Yufeng
Xiao, Lan
Xiao, Yin
author_facet Cai, Donglin
Gao, Wendong
Li, Zhelun
Zhang, Yufeng
Xiao, Lan
Xiao, Yin
author_sort Cai, Donglin
collection PubMed
description Macrophages are the most important innate immune cells that participate in various inflammation-related diseases. Therefore, macrophage-related pathological processes are essential targets in the diagnosis and treatment of diseases. Since nanoparticles (NPs) can be preferentially taken up by macrophages, NPs have attracted most attention for specific macrophage-targeting. In this review, the interactions between NPs and the immune system are introduced to help understand the pharmacokinetics and biodistribution of NPs in immune cells. The current design and strategy of NPs modification for specific macrophage-targeting are investigated and summarized.
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spelling pubmed-91390842022-05-28 Current Development of Nano-Drug Delivery to Target Macrophages Cai, Donglin Gao, Wendong Li, Zhelun Zhang, Yufeng Xiao, Lan Xiao, Yin Biomedicines Review Macrophages are the most important innate immune cells that participate in various inflammation-related diseases. Therefore, macrophage-related pathological processes are essential targets in the diagnosis and treatment of diseases. Since nanoparticles (NPs) can be preferentially taken up by macrophages, NPs have attracted most attention for specific macrophage-targeting. In this review, the interactions between NPs and the immune system are introduced to help understand the pharmacokinetics and biodistribution of NPs in immune cells. The current design and strategy of NPs modification for specific macrophage-targeting are investigated and summarized. MDPI 2022-05-23 /pmc/articles/PMC9139084/ /pubmed/35625939 http://dx.doi.org/10.3390/biomedicines10051203 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cai, Donglin
Gao, Wendong
Li, Zhelun
Zhang, Yufeng
Xiao, Lan
Xiao, Yin
Current Development of Nano-Drug Delivery to Target Macrophages
title Current Development of Nano-Drug Delivery to Target Macrophages
title_full Current Development of Nano-Drug Delivery to Target Macrophages
title_fullStr Current Development of Nano-Drug Delivery to Target Macrophages
title_full_unstemmed Current Development of Nano-Drug Delivery to Target Macrophages
title_short Current Development of Nano-Drug Delivery to Target Macrophages
title_sort current development of nano-drug delivery to target macrophages
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139084/
https://www.ncbi.nlm.nih.gov/pubmed/35625939
http://dx.doi.org/10.3390/biomedicines10051203
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