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Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases
The aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, is important for xenobiotic metabolism and binds to various endogenous and exogenous ligands present in the skin. AhR is known to be associated with diseases in various organs; however, its functions in chronic inflammator...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139118/ https://www.ncbi.nlm.nih.gov/pubmed/35625824 http://dx.doi.org/10.3390/biomedicines10051087 |
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author | Kim, Han-Bi Um, Ji-Young Chung, Bo-Young Kim, Jin-Cheol Kang, Seok-Young Park, Chun-Wook Kim, Hye-One |
author_facet | Kim, Han-Bi Um, Ji-Young Chung, Bo-Young Kim, Jin-Cheol Kang, Seok-Young Park, Chun-Wook Kim, Hye-One |
author_sort | Kim, Han-Bi |
collection | PubMed |
description | The aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, is important for xenobiotic metabolism and binds to various endogenous and exogenous ligands present in the skin. AhR is known to be associated with diseases in various organs; however, its functions in chronic inflammatory skin diseases, such as atopic dermatitis (AD) and psoriasis (PS), have recently been elucidated. Here, we discuss the molecular mechanisms of AhR related to chronic inflammatory skin diseases, such as AD and PS, and the mechanisms of action of AhR on the skin immune system. The importance of AhR molecular biological pathways, clinical features in animal models, and AhR ligands in skin diseases need to be investigated. In conclusion, the therapeutic effects of AhR ligands are demonstrated based on the relationship between AhR and skin diseases. Nevertheless, further studies are required to elucidate the detailed roles of AhR in chronic inflammatory skin diseases. |
format | Online Article Text |
id | pubmed-9139118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91391182022-05-28 Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases Kim, Han-Bi Um, Ji-Young Chung, Bo-Young Kim, Jin-Cheol Kang, Seok-Young Park, Chun-Wook Kim, Hye-One Biomedicines Review The aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, is important for xenobiotic metabolism and binds to various endogenous and exogenous ligands present in the skin. AhR is known to be associated with diseases in various organs; however, its functions in chronic inflammatory skin diseases, such as atopic dermatitis (AD) and psoriasis (PS), have recently been elucidated. Here, we discuss the molecular mechanisms of AhR related to chronic inflammatory skin diseases, such as AD and PS, and the mechanisms of action of AhR on the skin immune system. The importance of AhR molecular biological pathways, clinical features in animal models, and AhR ligands in skin diseases need to be investigated. In conclusion, the therapeutic effects of AhR ligands are demonstrated based on the relationship between AhR and skin diseases. Nevertheless, further studies are required to elucidate the detailed roles of AhR in chronic inflammatory skin diseases. MDPI 2022-05-07 /pmc/articles/PMC9139118/ /pubmed/35625824 http://dx.doi.org/10.3390/biomedicines10051087 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kim, Han-Bi Um, Ji-Young Chung, Bo-Young Kim, Jin-Cheol Kang, Seok-Young Park, Chun-Wook Kim, Hye-One Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases |
title | Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases |
title_full | Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases |
title_fullStr | Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases |
title_full_unstemmed | Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases |
title_short | Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases |
title_sort | aryl hydrocarbon receptors: evidence of therapeutic targets in chronic inflammatory skin diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139118/ https://www.ncbi.nlm.nih.gov/pubmed/35625824 http://dx.doi.org/10.3390/biomedicines10051087 |
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