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Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases

The aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, is important for xenobiotic metabolism and binds to various endogenous and exogenous ligands present in the skin. AhR is known to be associated with diseases in various organs; however, its functions in chronic inflammator...

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Autores principales: Kim, Han-Bi, Um, Ji-Young, Chung, Bo-Young, Kim, Jin-Cheol, Kang, Seok-Young, Park, Chun-Wook, Kim, Hye-One
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139118/
https://www.ncbi.nlm.nih.gov/pubmed/35625824
http://dx.doi.org/10.3390/biomedicines10051087
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author Kim, Han-Bi
Um, Ji-Young
Chung, Bo-Young
Kim, Jin-Cheol
Kang, Seok-Young
Park, Chun-Wook
Kim, Hye-One
author_facet Kim, Han-Bi
Um, Ji-Young
Chung, Bo-Young
Kim, Jin-Cheol
Kang, Seok-Young
Park, Chun-Wook
Kim, Hye-One
author_sort Kim, Han-Bi
collection PubMed
description The aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, is important for xenobiotic metabolism and binds to various endogenous and exogenous ligands present in the skin. AhR is known to be associated with diseases in various organs; however, its functions in chronic inflammatory skin diseases, such as atopic dermatitis (AD) and psoriasis (PS), have recently been elucidated. Here, we discuss the molecular mechanisms of AhR related to chronic inflammatory skin diseases, such as AD and PS, and the mechanisms of action of AhR on the skin immune system. The importance of AhR molecular biological pathways, clinical features in animal models, and AhR ligands in skin diseases need to be investigated. In conclusion, the therapeutic effects of AhR ligands are demonstrated based on the relationship between AhR and skin diseases. Nevertheless, further studies are required to elucidate the detailed roles of AhR in chronic inflammatory skin diseases.
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spelling pubmed-91391182022-05-28 Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases Kim, Han-Bi Um, Ji-Young Chung, Bo-Young Kim, Jin-Cheol Kang, Seok-Young Park, Chun-Wook Kim, Hye-One Biomedicines Review The aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, is important for xenobiotic metabolism and binds to various endogenous and exogenous ligands present in the skin. AhR is known to be associated with diseases in various organs; however, its functions in chronic inflammatory skin diseases, such as atopic dermatitis (AD) and psoriasis (PS), have recently been elucidated. Here, we discuss the molecular mechanisms of AhR related to chronic inflammatory skin diseases, such as AD and PS, and the mechanisms of action of AhR on the skin immune system. The importance of AhR molecular biological pathways, clinical features in animal models, and AhR ligands in skin diseases need to be investigated. In conclusion, the therapeutic effects of AhR ligands are demonstrated based on the relationship between AhR and skin diseases. Nevertheless, further studies are required to elucidate the detailed roles of AhR in chronic inflammatory skin diseases. MDPI 2022-05-07 /pmc/articles/PMC9139118/ /pubmed/35625824 http://dx.doi.org/10.3390/biomedicines10051087 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kim, Han-Bi
Um, Ji-Young
Chung, Bo-Young
Kim, Jin-Cheol
Kang, Seok-Young
Park, Chun-Wook
Kim, Hye-One
Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases
title Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases
title_full Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases
title_fullStr Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases
title_full_unstemmed Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases
title_short Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases
title_sort aryl hydrocarbon receptors: evidence of therapeutic targets in chronic inflammatory skin diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139118/
https://www.ncbi.nlm.nih.gov/pubmed/35625824
http://dx.doi.org/10.3390/biomedicines10051087
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