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Lack of Ecto-5′-Nucleotidase Protects Sensitized Mice against Allergen Challenge
Ecto-5′-nucleotidase (CD73), the ectoenzyme that together with CD39 is responsible for extracellular ATP hydrolysis and adenosine accumulation, regulates immune/inflammatory processes by controlling innate and acquired immunity cell functions. We previously demonstrated that CD73 is required for the...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139122/ https://www.ncbi.nlm.nih.gov/pubmed/35625624 http://dx.doi.org/10.3390/biom12050697 |
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author | Caiazzo, Elisabetta Cerqua, Ida Turiello, Roberta Riemma, Maria Antonietta De Palma, Giacomo Ialenti, Armando Roviezzo, Fiorentina Morello, Silvana Cicala, Carla |
author_facet | Caiazzo, Elisabetta Cerqua, Ida Turiello, Roberta Riemma, Maria Antonietta De Palma, Giacomo Ialenti, Armando Roviezzo, Fiorentina Morello, Silvana Cicala, Carla |
author_sort | Caiazzo, Elisabetta |
collection | PubMed |
description | Ecto-5′-nucleotidase (CD73), the ectoenzyme that together with CD39 is responsible for extracellular ATP hydrolysis and adenosine accumulation, regulates immune/inflammatory processes by controlling innate and acquired immunity cell functions. We previously demonstrated that CD73 is required for the assessment of a controlled allergic sensitization, in mice. Here, we evaluated the response to aerosolized allergen of female-sensitized mice lacking CD73 in comparison with their wild type counterpart. Results obtained show, in mice lacking CD73, the absence of airway hyperreactivity in response to an allergen challenge, paralleled by reduced airway CD23(+)B cells and IL4(+)T cells pulmonary accumulation together with reduced mast cells accumulation and degranulation. Our findings indicate CD73 as a potential therapeutic target for allergic asthma. |
format | Online Article Text |
id | pubmed-9139122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91391222022-05-28 Lack of Ecto-5′-Nucleotidase Protects Sensitized Mice against Allergen Challenge Caiazzo, Elisabetta Cerqua, Ida Turiello, Roberta Riemma, Maria Antonietta De Palma, Giacomo Ialenti, Armando Roviezzo, Fiorentina Morello, Silvana Cicala, Carla Biomolecules Brief Report Ecto-5′-nucleotidase (CD73), the ectoenzyme that together with CD39 is responsible for extracellular ATP hydrolysis and adenosine accumulation, regulates immune/inflammatory processes by controlling innate and acquired immunity cell functions. We previously demonstrated that CD73 is required for the assessment of a controlled allergic sensitization, in mice. Here, we evaluated the response to aerosolized allergen of female-sensitized mice lacking CD73 in comparison with their wild type counterpart. Results obtained show, in mice lacking CD73, the absence of airway hyperreactivity in response to an allergen challenge, paralleled by reduced airway CD23(+)B cells and IL4(+)T cells pulmonary accumulation together with reduced mast cells accumulation and degranulation. Our findings indicate CD73 as a potential therapeutic target for allergic asthma. MDPI 2022-05-13 /pmc/articles/PMC9139122/ /pubmed/35625624 http://dx.doi.org/10.3390/biom12050697 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Caiazzo, Elisabetta Cerqua, Ida Turiello, Roberta Riemma, Maria Antonietta De Palma, Giacomo Ialenti, Armando Roviezzo, Fiorentina Morello, Silvana Cicala, Carla Lack of Ecto-5′-Nucleotidase Protects Sensitized Mice against Allergen Challenge |
title | Lack of Ecto-5′-Nucleotidase Protects Sensitized Mice against Allergen Challenge |
title_full | Lack of Ecto-5′-Nucleotidase Protects Sensitized Mice against Allergen Challenge |
title_fullStr | Lack of Ecto-5′-Nucleotidase Protects Sensitized Mice against Allergen Challenge |
title_full_unstemmed | Lack of Ecto-5′-Nucleotidase Protects Sensitized Mice against Allergen Challenge |
title_short | Lack of Ecto-5′-Nucleotidase Protects Sensitized Mice against Allergen Challenge |
title_sort | lack of ecto-5′-nucleotidase protects sensitized mice against allergen challenge |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139122/ https://www.ncbi.nlm.nih.gov/pubmed/35625624 http://dx.doi.org/10.3390/biom12050697 |
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