Transcribed Ultraconserved Regions in Cancer

Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. This is notable, as lncRNAs are typically poorly conserved. TUCRs remain very understudied in many diseases, including cancer. In this review, we su...

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Detalles Bibliográficos
Autores principales: Gibert, Myron K., Sarkar, Aditya, Chagari, Bilhan, Roig-Laboy, Christian, Saha, Shekhar, Bednarek, Sylwia, Kefas, Benjamin, Hanif, Farina, Hudson, Kadie, Dube, Collin, Zhang, Ying, Abounader, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139194/
https://www.ncbi.nlm.nih.gov/pubmed/35626721
http://dx.doi.org/10.3390/cells11101684
Descripción
Sumario:Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. This is notable, as lncRNAs are typically poorly conserved. TUCRs remain very understudied in many diseases, including cancer. In this review, we summarize the current literature on TUCRs in cancer with respect to expression deregulation, functional roles, mechanisms of action, and clinical perspectives.

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