Transcribed Ultraconserved Regions in Cancer

Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. This is notable, as lncRNAs are typically poorly conserved. TUCRs remain very understudied in many diseases, including cancer. In this review, we su...

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Detalles Bibliográficos
Autores principales: Gibert, Myron K., Sarkar, Aditya, Chagari, Bilhan, Roig-Laboy, Christian, Saha, Shekhar, Bednarek, Sylwia, Kefas, Benjamin, Hanif, Farina, Hudson, Kadie, Dube, Collin, Zhang, Ying, Abounader, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139194/
https://www.ncbi.nlm.nih.gov/pubmed/35626721
http://dx.doi.org/10.3390/cells11101684
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author Gibert, Myron K.
Sarkar, Aditya
Chagari, Bilhan
Roig-Laboy, Christian
Saha, Shekhar
Bednarek, Sylwia
Kefas, Benjamin
Hanif, Farina
Hudson, Kadie
Dube, Collin
Zhang, Ying
Abounader, Roger
author_facet Gibert, Myron K.
Sarkar, Aditya
Chagari, Bilhan
Roig-Laboy, Christian
Saha, Shekhar
Bednarek, Sylwia
Kefas, Benjamin
Hanif, Farina
Hudson, Kadie
Dube, Collin
Zhang, Ying
Abounader, Roger
author_sort Gibert, Myron K.
collection PubMed
description Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. This is notable, as lncRNAs are typically poorly conserved. TUCRs remain very understudied in many diseases, including cancer. In this review, we summarize the current literature on TUCRs in cancer with respect to expression deregulation, functional roles, mechanisms of action, and clinical perspectives.
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spelling pubmed-91391942022-05-28 Transcribed Ultraconserved Regions in Cancer Gibert, Myron K. Sarkar, Aditya Chagari, Bilhan Roig-Laboy, Christian Saha, Shekhar Bednarek, Sylwia Kefas, Benjamin Hanif, Farina Hudson, Kadie Dube, Collin Zhang, Ying Abounader, Roger Cells Review Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. This is notable, as lncRNAs are typically poorly conserved. TUCRs remain very understudied in many diseases, including cancer. In this review, we summarize the current literature on TUCRs in cancer with respect to expression deregulation, functional roles, mechanisms of action, and clinical perspectives. MDPI 2022-05-19 /pmc/articles/PMC9139194/ /pubmed/35626721 http://dx.doi.org/10.3390/cells11101684 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gibert, Myron K.
Sarkar, Aditya
Chagari, Bilhan
Roig-Laboy, Christian
Saha, Shekhar
Bednarek, Sylwia
Kefas, Benjamin
Hanif, Farina
Hudson, Kadie
Dube, Collin
Zhang, Ying
Abounader, Roger
Transcribed Ultraconserved Regions in Cancer
title Transcribed Ultraconserved Regions in Cancer
title_full Transcribed Ultraconserved Regions in Cancer
title_fullStr Transcribed Ultraconserved Regions in Cancer
title_full_unstemmed Transcribed Ultraconserved Regions in Cancer
title_short Transcribed Ultraconserved Regions in Cancer
title_sort transcribed ultraconserved regions in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139194/
https://www.ncbi.nlm.nih.gov/pubmed/35626721
http://dx.doi.org/10.3390/cells11101684
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