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Squamous Cell Carcinoma Antigen: Clinical Application and Research Status
The squamous cell carcinoma antigen (SCCA) is a tumor marker that has gained increasing attention for its biological functions and significance in normal physiological and pathological processes. Not only SCCA but also circulating immune complexes of SCCA and immunoglobulin M (IgM) are involved in n...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139199/ https://www.ncbi.nlm.nih.gov/pubmed/35626221 http://dx.doi.org/10.3390/diagnostics12051065 |
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author | Zhu, Huange |
author_facet | Zhu, Huange |
author_sort | Zhu, Huange |
collection | PubMed |
description | The squamous cell carcinoma antigen (SCCA) is a tumor marker that has gained increasing attention for its biological functions and significance in normal physiological and pathological processes. Not only SCCA but also circulating immune complexes of SCCA and immunoglobulin M (IgM) are involved in normal physiological and pathological processes, providing a background for numerous clinical studies aimed at assessing the potential role of SCCA, SCCA–IgM, and SCCA isoform complexes in clinical practice. Previous studies support the clinical value of SCCA as a tumor marker for either diagnosing squamous cancers or monitoring the response to radiotherapy or chemotherapy, tumor relapse, and treatment failure. However, these studies show contrasting results, making the diagnostic or prognostic value of SCCA controversial. To reduce clinical heterogeneity across studies and achieve a more accurate and reliable comparison of results, a standardized detection method, scoring system, and cutoff level need to be established. Moreover, despite the fact that performances of different methods are comparable, the dynamic observation of tumor marker kinetics should be conducted under the same method. |
format | Online Article Text |
id | pubmed-9139199 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91391992022-05-28 Squamous Cell Carcinoma Antigen: Clinical Application and Research Status Zhu, Huange Diagnostics (Basel) Review The squamous cell carcinoma antigen (SCCA) is a tumor marker that has gained increasing attention for its biological functions and significance in normal physiological and pathological processes. Not only SCCA but also circulating immune complexes of SCCA and immunoglobulin M (IgM) are involved in normal physiological and pathological processes, providing a background for numerous clinical studies aimed at assessing the potential role of SCCA, SCCA–IgM, and SCCA isoform complexes in clinical practice. Previous studies support the clinical value of SCCA as a tumor marker for either diagnosing squamous cancers or monitoring the response to radiotherapy or chemotherapy, tumor relapse, and treatment failure. However, these studies show contrasting results, making the diagnostic or prognostic value of SCCA controversial. To reduce clinical heterogeneity across studies and achieve a more accurate and reliable comparison of results, a standardized detection method, scoring system, and cutoff level need to be established. Moreover, despite the fact that performances of different methods are comparable, the dynamic observation of tumor marker kinetics should be conducted under the same method. MDPI 2022-04-24 /pmc/articles/PMC9139199/ /pubmed/35626221 http://dx.doi.org/10.3390/diagnostics12051065 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhu, Huange Squamous Cell Carcinoma Antigen: Clinical Application and Research Status |
title | Squamous Cell Carcinoma Antigen: Clinical Application and Research Status |
title_full | Squamous Cell Carcinoma Antigen: Clinical Application and Research Status |
title_fullStr | Squamous Cell Carcinoma Antigen: Clinical Application and Research Status |
title_full_unstemmed | Squamous Cell Carcinoma Antigen: Clinical Application and Research Status |
title_short | Squamous Cell Carcinoma Antigen: Clinical Application and Research Status |
title_sort | squamous cell carcinoma antigen: clinical application and research status |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139199/ https://www.ncbi.nlm.nih.gov/pubmed/35626221 http://dx.doi.org/10.3390/diagnostics12051065 |
work_keys_str_mv | AT zhuhuange squamouscellcarcinomaantigenclinicalapplicationandresearchstatus |