Cargando…

Squamous Cell Carcinoma Antigen: Clinical Application and Research Status

The squamous cell carcinoma antigen (SCCA) is a tumor marker that has gained increasing attention for its biological functions and significance in normal physiological and pathological processes. Not only SCCA but also circulating immune complexes of SCCA and immunoglobulin M (IgM) are involved in n...

Descripción completa

Detalles Bibliográficos
Autor principal: Zhu, Huange
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139199/
https://www.ncbi.nlm.nih.gov/pubmed/35626221
http://dx.doi.org/10.3390/diagnostics12051065
_version_ 1784714803531481088
author Zhu, Huange
author_facet Zhu, Huange
author_sort Zhu, Huange
collection PubMed
description The squamous cell carcinoma antigen (SCCA) is a tumor marker that has gained increasing attention for its biological functions and significance in normal physiological and pathological processes. Not only SCCA but also circulating immune complexes of SCCA and immunoglobulin M (IgM) are involved in normal physiological and pathological processes, providing a background for numerous clinical studies aimed at assessing the potential role of SCCA, SCCA–IgM, and SCCA isoform complexes in clinical practice. Previous studies support the clinical value of SCCA as a tumor marker for either diagnosing squamous cancers or monitoring the response to radiotherapy or chemotherapy, tumor relapse, and treatment failure. However, these studies show contrasting results, making the diagnostic or prognostic value of SCCA controversial. To reduce clinical heterogeneity across studies and achieve a more accurate and reliable comparison of results, a standardized detection method, scoring system, and cutoff level need to be established. Moreover, despite the fact that performances of different methods are comparable, the dynamic observation of tumor marker kinetics should be conducted under the same method.
format Online
Article
Text
id pubmed-9139199
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91391992022-05-28 Squamous Cell Carcinoma Antigen: Clinical Application and Research Status Zhu, Huange Diagnostics (Basel) Review The squamous cell carcinoma antigen (SCCA) is a tumor marker that has gained increasing attention for its biological functions and significance in normal physiological and pathological processes. Not only SCCA but also circulating immune complexes of SCCA and immunoglobulin M (IgM) are involved in normal physiological and pathological processes, providing a background for numerous clinical studies aimed at assessing the potential role of SCCA, SCCA–IgM, and SCCA isoform complexes in clinical practice. Previous studies support the clinical value of SCCA as a tumor marker for either diagnosing squamous cancers or monitoring the response to radiotherapy or chemotherapy, tumor relapse, and treatment failure. However, these studies show contrasting results, making the diagnostic or prognostic value of SCCA controversial. To reduce clinical heterogeneity across studies and achieve a more accurate and reliable comparison of results, a standardized detection method, scoring system, and cutoff level need to be established. Moreover, despite the fact that performances of different methods are comparable, the dynamic observation of tumor marker kinetics should be conducted under the same method. MDPI 2022-04-24 /pmc/articles/PMC9139199/ /pubmed/35626221 http://dx.doi.org/10.3390/diagnostics12051065 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhu, Huange
Squamous Cell Carcinoma Antigen: Clinical Application and Research Status
title Squamous Cell Carcinoma Antigen: Clinical Application and Research Status
title_full Squamous Cell Carcinoma Antigen: Clinical Application and Research Status
title_fullStr Squamous Cell Carcinoma Antigen: Clinical Application and Research Status
title_full_unstemmed Squamous Cell Carcinoma Antigen: Clinical Application and Research Status
title_short Squamous Cell Carcinoma Antigen: Clinical Application and Research Status
title_sort squamous cell carcinoma antigen: clinical application and research status
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139199/
https://www.ncbi.nlm.nih.gov/pubmed/35626221
http://dx.doi.org/10.3390/diagnostics12051065
work_keys_str_mv AT zhuhuange squamouscellcarcinomaantigenclinicalapplicationandresearchstatus