How Phosphofructokinase-1 Promotes PI3K and YAP/TAZ in Cancer: Therapeutic Perspectives

SIMPLE SUMMARY: We propose that PFK1 promotes a positive feedback loop with PI3K/AKT and YAP/TAZ signaling pathways in cancer cells. Therefore, targeting PFK1 (or its product F-1,6-BP) could improve the efficacy of PI3K and YAP/TAZ inhibitors currently tested in clinical trials. To this aim, we sugg...

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Detalles Bibliográficos
Autores principales: Simula, Luca, Alifano, Marco, Icard, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139230/
https://www.ncbi.nlm.nih.gov/pubmed/35626081
http://dx.doi.org/10.3390/cancers14102478

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