Cargando…

Molecular Diagnostic Review of Diffuse Large B-Cell Lymphoma and Its Tumor Microenvironment

Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. It is a clinically and morphologically heterogeneous entity that has continued to resist complete subtyping. Molecular subtyping efforts emerged in earnest with the advent of gene expression profiling (GEP). This molecula...

Descripción completa

Detalles Bibliográficos
Autores principales: Ta, Robert, Yang, David, Hirt, Christian, Drago, Thomas, Flavin, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139291/
https://www.ncbi.nlm.nih.gov/pubmed/35626243
http://dx.doi.org/10.3390/diagnostics12051087
_version_ 1784714824836448256
author Ta, Robert
Yang, David
Hirt, Christian
Drago, Thomas
Flavin, Richard
author_facet Ta, Robert
Yang, David
Hirt, Christian
Drago, Thomas
Flavin, Richard
author_sort Ta, Robert
collection PubMed
description Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. It is a clinically and morphologically heterogeneous entity that has continued to resist complete subtyping. Molecular subtyping efforts emerged in earnest with the advent of gene expression profiling (GEP). This molecular subtyping approach has continued to evolve simultaneously with others including immunohistochemistry and more modern genomic approaches. Recently, the veritable explosion of genomic data availability and evolving computational methodologies have provided additional avenues, by which further understanding and subclassification of DBLCLs is possible. The goal of this review is to provide a historical overview of the major classification timepoints in the molecular subtyping of DLBCL, from gene expression profiling to present day understanding.
format Online
Article
Text
id pubmed-9139291
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91392912022-05-28 Molecular Diagnostic Review of Diffuse Large B-Cell Lymphoma and Its Tumor Microenvironment Ta, Robert Yang, David Hirt, Christian Drago, Thomas Flavin, Richard Diagnostics (Basel) Review Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. It is a clinically and morphologically heterogeneous entity that has continued to resist complete subtyping. Molecular subtyping efforts emerged in earnest with the advent of gene expression profiling (GEP). This molecular subtyping approach has continued to evolve simultaneously with others including immunohistochemistry and more modern genomic approaches. Recently, the veritable explosion of genomic data availability and evolving computational methodologies have provided additional avenues, by which further understanding and subclassification of DBLCLs is possible. The goal of this review is to provide a historical overview of the major classification timepoints in the molecular subtyping of DLBCL, from gene expression profiling to present day understanding. MDPI 2022-04-27 /pmc/articles/PMC9139291/ /pubmed/35626243 http://dx.doi.org/10.3390/diagnostics12051087 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ta, Robert
Yang, David
Hirt, Christian
Drago, Thomas
Flavin, Richard
Molecular Diagnostic Review of Diffuse Large B-Cell Lymphoma and Its Tumor Microenvironment
title Molecular Diagnostic Review of Diffuse Large B-Cell Lymphoma and Its Tumor Microenvironment
title_full Molecular Diagnostic Review of Diffuse Large B-Cell Lymphoma and Its Tumor Microenvironment
title_fullStr Molecular Diagnostic Review of Diffuse Large B-Cell Lymphoma and Its Tumor Microenvironment
title_full_unstemmed Molecular Diagnostic Review of Diffuse Large B-Cell Lymphoma and Its Tumor Microenvironment
title_short Molecular Diagnostic Review of Diffuse Large B-Cell Lymphoma and Its Tumor Microenvironment
title_sort molecular diagnostic review of diffuse large b-cell lymphoma and its tumor microenvironment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139291/
https://www.ncbi.nlm.nih.gov/pubmed/35626243
http://dx.doi.org/10.3390/diagnostics12051087
work_keys_str_mv AT tarobert moleculardiagnosticreviewofdiffuselargebcelllymphomaanditstumormicroenvironment
AT yangdavid moleculardiagnosticreviewofdiffuselargebcelllymphomaanditstumormicroenvironment
AT hirtchristian moleculardiagnosticreviewofdiffuselargebcelllymphomaanditstumormicroenvironment
AT dragothomas moleculardiagnosticreviewofdiffuselargebcelllymphomaanditstumormicroenvironment
AT flavinrichard moleculardiagnosticreviewofdiffuselargebcelllymphomaanditstumormicroenvironment