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Molecular Diagnostic Review of Diffuse Large B-Cell Lymphoma and Its Tumor Microenvironment
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. It is a clinically and morphologically heterogeneous entity that has continued to resist complete subtyping. Molecular subtyping efforts emerged in earnest with the advent of gene expression profiling (GEP). This molecula...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139291/ https://www.ncbi.nlm.nih.gov/pubmed/35626243 http://dx.doi.org/10.3390/diagnostics12051087 |
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author | Ta, Robert Yang, David Hirt, Christian Drago, Thomas Flavin, Richard |
author_facet | Ta, Robert Yang, David Hirt, Christian Drago, Thomas Flavin, Richard |
author_sort | Ta, Robert |
collection | PubMed |
description | Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. It is a clinically and morphologically heterogeneous entity that has continued to resist complete subtyping. Molecular subtyping efforts emerged in earnest with the advent of gene expression profiling (GEP). This molecular subtyping approach has continued to evolve simultaneously with others including immunohistochemistry and more modern genomic approaches. Recently, the veritable explosion of genomic data availability and evolving computational methodologies have provided additional avenues, by which further understanding and subclassification of DBLCLs is possible. The goal of this review is to provide a historical overview of the major classification timepoints in the molecular subtyping of DLBCL, from gene expression profiling to present day understanding. |
format | Online Article Text |
id | pubmed-9139291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91392912022-05-28 Molecular Diagnostic Review of Diffuse Large B-Cell Lymphoma and Its Tumor Microenvironment Ta, Robert Yang, David Hirt, Christian Drago, Thomas Flavin, Richard Diagnostics (Basel) Review Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. It is a clinically and morphologically heterogeneous entity that has continued to resist complete subtyping. Molecular subtyping efforts emerged in earnest with the advent of gene expression profiling (GEP). This molecular subtyping approach has continued to evolve simultaneously with others including immunohistochemistry and more modern genomic approaches. Recently, the veritable explosion of genomic data availability and evolving computational methodologies have provided additional avenues, by which further understanding and subclassification of DBLCLs is possible. The goal of this review is to provide a historical overview of the major classification timepoints in the molecular subtyping of DLBCL, from gene expression profiling to present day understanding. MDPI 2022-04-27 /pmc/articles/PMC9139291/ /pubmed/35626243 http://dx.doi.org/10.3390/diagnostics12051087 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ta, Robert Yang, David Hirt, Christian Drago, Thomas Flavin, Richard Molecular Diagnostic Review of Diffuse Large B-Cell Lymphoma and Its Tumor Microenvironment |
title | Molecular Diagnostic Review of Diffuse Large B-Cell Lymphoma and Its Tumor Microenvironment |
title_full | Molecular Diagnostic Review of Diffuse Large B-Cell Lymphoma and Its Tumor Microenvironment |
title_fullStr | Molecular Diagnostic Review of Diffuse Large B-Cell Lymphoma and Its Tumor Microenvironment |
title_full_unstemmed | Molecular Diagnostic Review of Diffuse Large B-Cell Lymphoma and Its Tumor Microenvironment |
title_short | Molecular Diagnostic Review of Diffuse Large B-Cell Lymphoma and Its Tumor Microenvironment |
title_sort | molecular diagnostic review of diffuse large b-cell lymphoma and its tumor microenvironment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139291/ https://www.ncbi.nlm.nih.gov/pubmed/35626243 http://dx.doi.org/10.3390/diagnostics12051087 |
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