Mutational Activation of the NRF2 Pathway Upregulates Kynureninase Resulting in Tumor Immunosuppression and Poor Outcome in Lung Adenocarcinoma

SIMPLE SUMMARY: Activation of the Nuclear factor-erythroid factor 2-related factor 2 (NRF2) pathway through gain-of-function mutations or loss-of-function of its suppressor Kelch-like ECH-associated protein 1 (KEAP1) is frequent in lung cancer. NRF2 activation has also been reported to alter the tum...

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Detalles Bibliográficos
Autores principales: Fahrmann, Johannes F., Tanaka, Ichidai, Irajizad, Ehsan, Mao, Xiangying, Dennison, Jennifer B., Murage, Eunice, Casabar, Julian, Mayo, Jeffrey, Peng, Qian, Celiktas, Muge, Vykoukal, Jody V., Park, Soyoung, Taguchi, Ayumu, Delgado, Oliver, Tripathi, Satyendra C., Katayama, Hiroyuki, Soto, Luisa Maren Solis, Rodriguez-Canales, Jaime, Behrens, Carmen, Wistuba, Ignacio, Hanash, Samir, Ostrin, Edwin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139317/
https://www.ncbi.nlm.nih.gov/pubmed/35626147
http://dx.doi.org/10.3390/cancers14102543

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