Alterations of Mitochondrial Network by Cigarette Smoking and E-Cigarette Vaping

Toxins present in cigarette and e-cigarette smoke constitute a significant cause of illnesses and are known to have fatal health impacts. Specific mechanisms by which toxins present in smoke impair cell repair are still being researched and are of prime interest for developing more effective treatme...

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Autores principales: Kanithi, Manasa, Junapudi, Sunil, Shah, Syed Islamuddin, Matta Reddy, Alavala, Ullah, Ghanim, Chidipi, Bojjibabu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139349/
https://www.ncbi.nlm.nih.gov/pubmed/35626724
http://dx.doi.org/10.3390/cells11101688
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author Kanithi, Manasa
Junapudi, Sunil
Shah, Syed Islamuddin
Matta Reddy, Alavala
Ullah, Ghanim
Chidipi, Bojjibabu
author_facet Kanithi, Manasa
Junapudi, Sunil
Shah, Syed Islamuddin
Matta Reddy, Alavala
Ullah, Ghanim
Chidipi, Bojjibabu
author_sort Kanithi, Manasa
collection PubMed
description Toxins present in cigarette and e-cigarette smoke constitute a significant cause of illnesses and are known to have fatal health impacts. Specific mechanisms by which toxins present in smoke impair cell repair are still being researched and are of prime interest for developing more effective treatments. Current literature suggests toxins present in cigarette smoke and aerosolized e-vapor trigger abnormal intercellular responses, damage mitochondrial function, and consequently disrupt the homeostasis of the organelle’s biochemical processes by increasing reactive oxidative species. Increased oxidative stress sets off a cascade of molecular events, disrupting optimal mitochondrial morphology and homeostasis. Furthermore, smoking-induced oxidative stress may also amalgamate with other health factors to contribute to various pathophysiological processes. An increasing number of studies show that toxins may affect mitochondria even through exposure to secondhand or thirdhand smoke. This review assesses the impact of toxins present in tobacco smoke and e-vapor on mitochondrial health, networking, and critical structural processes, including mitochondria fission, fusion, hyper-fusion, fragmentation, and mitophagy. The efforts are focused on discussing current evidence linking toxins present in first, second, and thirdhand smoke to mitochondrial dysfunction.
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spelling pubmed-91393492022-05-28 Alterations of Mitochondrial Network by Cigarette Smoking and E-Cigarette Vaping Kanithi, Manasa Junapudi, Sunil Shah, Syed Islamuddin Matta Reddy, Alavala Ullah, Ghanim Chidipi, Bojjibabu Cells Review Toxins present in cigarette and e-cigarette smoke constitute a significant cause of illnesses and are known to have fatal health impacts. Specific mechanisms by which toxins present in smoke impair cell repair are still being researched and are of prime interest for developing more effective treatments. Current literature suggests toxins present in cigarette smoke and aerosolized e-vapor trigger abnormal intercellular responses, damage mitochondrial function, and consequently disrupt the homeostasis of the organelle’s biochemical processes by increasing reactive oxidative species. Increased oxidative stress sets off a cascade of molecular events, disrupting optimal mitochondrial morphology and homeostasis. Furthermore, smoking-induced oxidative stress may also amalgamate with other health factors to contribute to various pathophysiological processes. An increasing number of studies show that toxins may affect mitochondria even through exposure to secondhand or thirdhand smoke. This review assesses the impact of toxins present in tobacco smoke and e-vapor on mitochondrial health, networking, and critical structural processes, including mitochondria fission, fusion, hyper-fusion, fragmentation, and mitophagy. The efforts are focused on discussing current evidence linking toxins present in first, second, and thirdhand smoke to mitochondrial dysfunction. MDPI 2022-05-19 /pmc/articles/PMC9139349/ /pubmed/35626724 http://dx.doi.org/10.3390/cells11101688 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kanithi, Manasa
Junapudi, Sunil
Shah, Syed Islamuddin
Matta Reddy, Alavala
Ullah, Ghanim
Chidipi, Bojjibabu
Alterations of Mitochondrial Network by Cigarette Smoking and E-Cigarette Vaping
title Alterations of Mitochondrial Network by Cigarette Smoking and E-Cigarette Vaping
title_full Alterations of Mitochondrial Network by Cigarette Smoking and E-Cigarette Vaping
title_fullStr Alterations of Mitochondrial Network by Cigarette Smoking and E-Cigarette Vaping
title_full_unstemmed Alterations of Mitochondrial Network by Cigarette Smoking and E-Cigarette Vaping
title_short Alterations of Mitochondrial Network by Cigarette Smoking and E-Cigarette Vaping
title_sort alterations of mitochondrial network by cigarette smoking and e-cigarette vaping
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139349/
https://www.ncbi.nlm.nih.gov/pubmed/35626724
http://dx.doi.org/10.3390/cells11101688
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