Ultrasound Shear Wave Elastography, Shear Wave Dispersion and Attenuation Imaging of Pediatric Liver Disease with Histological Correlation

Aim: To evaluate the feasibility of multiple ultrasound markers for the non-invasive characterization of fibrosis, inflammation and steatosis in the liver in pediatric patients. Materials and methods: The quantitative ultrasound measures shear wave elastography (SWE), shear wave dispersion (SWD) and...

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Autores principales: Cetinic, Ivan, de Lange, Charlotte, Simrén, Yvonne, Ekvall, Nils, Östling, Maja, Stén, Liselotte, Boström, Håkan, Lagerstrand, Kerstin, Hebelka, Hanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139364/
https://www.ncbi.nlm.nih.gov/pubmed/35626865
http://dx.doi.org/10.3390/children9050692
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author Cetinic, Ivan
de Lange, Charlotte
Simrén, Yvonne
Ekvall, Nils
Östling, Maja
Stén, Liselotte
Boström, Håkan
Lagerstrand, Kerstin
Hebelka, Hanna
author_facet Cetinic, Ivan
de Lange, Charlotte
Simrén, Yvonne
Ekvall, Nils
Östling, Maja
Stén, Liselotte
Boström, Håkan
Lagerstrand, Kerstin
Hebelka, Hanna
author_sort Cetinic, Ivan
collection PubMed
description Aim: To evaluate the feasibility of multiple ultrasound markers for the non-invasive characterization of fibrosis, inflammation and steatosis in the liver in pediatric patients. Materials and methods: The quantitative ultrasound measures shear wave elastography (SWE), shear wave dispersion (SWD) and attenuation imaging (ATI) were compared and correlated with percutaneous liver biopsies and corresponding measures in a control cohort. Results: The median age of the 32 patients was 12.1 years (range 0.1–17.9), and that of the 15 controls was 11.8 years (range: 2.6–16.6). Results: There was a significant difference in SWE values between histologic grades of fibrosis (p = 0.003), with a positive correlation according to the grade (r = 0.7; p < 0.0001). Overall, a difference in SWD values between grades of inflammation was found (p = 0.009) but with a lack of correlation (r = 0.1; p = 0.67). Comparing inflammation grades 0–1 (median:13.6 m/s kHz [min; max; 8.4; 17.5]) versus grades 2–3 (16.3 m/s kHz [14.6; 24.2]) showed significant differences between the groups (p = 0.003). In the 30 individuals with a steatosis score of 0, ATI was measured in 23 cases with a median value of 0.56 dB/cm/MHz. Conclusion: Comprehensive ultrasound analysis was feasible to apply in children and has the potential to reflect the various components of liver affection non-invasively. Larger studies are necessary to conclude to what extent these image-based markers can classify the grade of fibrosis, inflammation and steatosis.
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spelling pubmed-91393642022-05-28 Ultrasound Shear Wave Elastography, Shear Wave Dispersion and Attenuation Imaging of Pediatric Liver Disease with Histological Correlation Cetinic, Ivan de Lange, Charlotte Simrén, Yvonne Ekvall, Nils Östling, Maja Stén, Liselotte Boström, Håkan Lagerstrand, Kerstin Hebelka, Hanna Children (Basel) Article Aim: To evaluate the feasibility of multiple ultrasound markers for the non-invasive characterization of fibrosis, inflammation and steatosis in the liver in pediatric patients. Materials and methods: The quantitative ultrasound measures shear wave elastography (SWE), shear wave dispersion (SWD) and attenuation imaging (ATI) were compared and correlated with percutaneous liver biopsies and corresponding measures in a control cohort. Results: The median age of the 32 patients was 12.1 years (range 0.1–17.9), and that of the 15 controls was 11.8 years (range: 2.6–16.6). Results: There was a significant difference in SWE values between histologic grades of fibrosis (p = 0.003), with a positive correlation according to the grade (r = 0.7; p < 0.0001). Overall, a difference in SWD values between grades of inflammation was found (p = 0.009) but with a lack of correlation (r = 0.1; p = 0.67). Comparing inflammation grades 0–1 (median:13.6 m/s kHz [min; max; 8.4; 17.5]) versus grades 2–3 (16.3 m/s kHz [14.6; 24.2]) showed significant differences between the groups (p = 0.003). In the 30 individuals with a steatosis score of 0, ATI was measured in 23 cases with a median value of 0.56 dB/cm/MHz. Conclusion: Comprehensive ultrasound analysis was feasible to apply in children and has the potential to reflect the various components of liver affection non-invasively. Larger studies are necessary to conclude to what extent these image-based markers can classify the grade of fibrosis, inflammation and steatosis. MDPI 2022-05-09 /pmc/articles/PMC9139364/ /pubmed/35626865 http://dx.doi.org/10.3390/children9050692 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cetinic, Ivan
de Lange, Charlotte
Simrén, Yvonne
Ekvall, Nils
Östling, Maja
Stén, Liselotte
Boström, Håkan
Lagerstrand, Kerstin
Hebelka, Hanna
Ultrasound Shear Wave Elastography, Shear Wave Dispersion and Attenuation Imaging of Pediatric Liver Disease with Histological Correlation
title Ultrasound Shear Wave Elastography, Shear Wave Dispersion and Attenuation Imaging of Pediatric Liver Disease with Histological Correlation
title_full Ultrasound Shear Wave Elastography, Shear Wave Dispersion and Attenuation Imaging of Pediatric Liver Disease with Histological Correlation
title_fullStr Ultrasound Shear Wave Elastography, Shear Wave Dispersion and Attenuation Imaging of Pediatric Liver Disease with Histological Correlation
title_full_unstemmed Ultrasound Shear Wave Elastography, Shear Wave Dispersion and Attenuation Imaging of Pediatric Liver Disease with Histological Correlation
title_short Ultrasound Shear Wave Elastography, Shear Wave Dispersion and Attenuation Imaging of Pediatric Liver Disease with Histological Correlation
title_sort ultrasound shear wave elastography, shear wave dispersion and attenuation imaging of pediatric liver disease with histological correlation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139364/
https://www.ncbi.nlm.nih.gov/pubmed/35626865
http://dx.doi.org/10.3390/children9050692
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